32399-48-7

Usage

Uses

Used in Pharmaceutical Industry:
2,4,6-Cycloheptatriene-1-carbonyl chloride (6CI,8CI,9CI) is used as a synthetic intermediate for the development of various pharmaceuticals. Its reactivity allows for the creation of complex molecular structures that can be utilized in the formulation of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4,6-Cycloheptatriene-1-carbonyl chloride (6CI,8CI,9CI) is employed as a key component in the synthesis of compounds that have applications in crop protection and pest control, contributing to the development of effective and targeted agrochemicals.
Used in Organic Synthesis as a Reagent:
2,4,6-Cycloheptatriene-1-carbonyl chloride (6CI,8CI,9CI) is utilized as a reagent in organic synthesis processes, particularly for the production of carboxylic acids, esters, and amides. Its ability to participate in various chemical reactions makes it a versatile component in the synthesis of a wide range of organic compounds.

Upstream product

• 27332-37-2 ethyl cyclohepta-2,4,6-trienecarboxylate 
• 13612-59-4 cyclohepta-2,4,6-triene-1-carbonitrile 
• 4440-40-8 cyclohepta-2,4,6-trienecarboxylic acid 

Downstream Products

• 97847-64-8 2,4,6-Cycloheptatrien-1-yl-phenylketon 
• 15598-84-2 9-Phenyl-9-hydroxy-tricyclo<3.3.2.0^2,8>decadien-(3,6) 
• 15719-09-2 tricyclo[3.3.2.0^2,8]deca-6,9-dien-4-one 
• 54549-58-5 9α-Formyl-barbaralan 
• 283-50-1 Bicyclo<3.3.2>decane 
• 104876-73-5 anti-3-(4-Methoxybenzoyl)-N-methyl-6,7-diaza-exo-tricyclo<3.2.2.0^2,4>non-8-en-6,7-dicarboximid 
• 104876-72-4 anti-3-Benzoyl-N-methyl-6,7-diaza-exo-tricyclo<3.2.2.0^2,4>non-8-en-6,7-dicarboximid 
• 53486-75-2 N-Methyl-7-cycloheptatriencarbonsaeureamid 
• 26902-48-7 cyclohepta-2,4,6-trienecarboxamide 
• 97847-94-4 2,4,6-Cycloheptatrien-1-yl-(4-methoxyphenyl)keton 
• 32399-49-8 N,N-dimethyl-1,3,5-cycloheptatriene-7-carboxamide 
• 451-40-1 phenyl benzyl ketone 
• 27332-45-2 2,4,6-Cycloheptatrien-1-yl-methylketon 
• 6006-24-2 tricyclo<3.3.1.0^2,8>nona-3,6-dien-9-one 

Relevant academic research and scientific papers

Ion pair acidities and aggregation of some amide and oxazoline enolates in THF

Equilibrium lithium ion pair acidities at 25 °C have been determined in THF for the following acetamides: N,N-dimethyl-(4-biphenylyl)acetamide (1) (19.69), N,N-diethyl-(4-biphenylyl)acetamide (2) (20.30), N,N-dimethyl- diphenylacetamide (3) (20.76), N,N-diethyl-diphenylacetamide (4) (21.99), and 1-(diphenylmethylcarbonyl)pyrrolidine (5) (21.08). These acidity data compare well with those previously reported for the corresponding cesium enolates. Lithium and cesium ion pair acidities in THF are reported for two oxazolines: 2-(4-biphenylylmethyl)oxazoline (6) (Li, 21.53; Cs, 25.49) and (E)-(4S,5R)- 2-(4-biphenylylmethyl)-4-methoxymethyl-5-phenyloxazoline (7) (Li, 20.10; Cs 24.21). Studies of their acidities over a wide range of concentrations indicate that all of the lithium and cesium enolates of 1-7 are essentially monomeric at concentrations ranging from 10-3 to 10-4 M. Traces of dimer were detected for the lithium enolates of amides 1 and 2 and for the cesium enolate of oxazoline 6. Their dimerization constants (M-1) were found to be about 450, 200, and 150, respectively. All of the other lithium and cesium enolate probably form small amounts of dimer, but the dimerization constant of -1 is below the limit of precision of our spectroscopic method.

Heptafulvenone, vinylketene, butadienylketene, and allenylketene - Facile generation, observation, and radical reaction with TEMPO

Heptafulvenone (1), vinylketene (11), 1,3-butadienylketene [(E)-15], and allenylketene (21) have been prepared by reaction of the corresponding acyl chlorides with 1,8-bis(dimethylamino)naphthalene as long-lived species in solution at room temperature, and their ketenyl IR bands observed under these conditions for the first time, at 2101, 2118, 2111, 2117 cm-1, respectively. These unsaturated ketenes react with tetramethylpiperidinyloxyl (TEMPO, TO.) with initial attack at the carbonyl carbon giving delocalized radicals which give from 1 a mixture of the ring contracted o-, m-, and p-formylbenzoates O=CHC6H4CO2T (6) and the bis-(cycloheptatrienyl) dimer 7. The products from 11, (E)-15, and 21 are the bis(TEMPO) adducts (E,Z)-TOCH2CH= CHCO2T (12), (E,E)-TOCH2CH=CHCH=CHCO2T (17), and (E,Z)-CH2=C(OT)CH=CHCO2T (22), respectively.