325856-49-3Relevant academic research and scientific papers
Highly enantioselective acylation of chlorohydrins using Amano AK lipase from P. fluorescens immobilized on silk fibroin-alginate spheres
Ferreira, Irlon M.,Nishimura, Rodolfo H.V.,Souza, Ana B. Dos A.,Clososki, Giuliano C.,Yoshioka, Sergio A.,Porto, André L.M.
supporting information, p. 5062 - 5065 (2015/01/09)
Aromatic, allylic, and aliphatic compounds containing a chlorohydrin group were selected as substrates for the enzymatic kinetic resolution mediated by Amano AK lipase from Pseudomonas fluorescens immobilized in silk friboin-alginate spheres. Thus, the en
'Green' synthesis of important pharmaceutical building blocks: Enzymatic access to enantiomerically pure α-chloroalcohols
Zhu, Dunming,Mukherjee, Chandrani,Hua, Ling
, p. 3275 - 3278 (2007/10/03)
Thirty one recombinant ketoreductase enzymes were screened for the reduction of six α-chloroketones, the precursors of pharmaceutically valuable α-chloroalcohols. Several highly active and enantioselective ketoreductases were found and their applications
Highly enantioselective and regioselective biocatalytic azidolysis of aromatic epoxides
Spelberg, Jeffrey H. Lutje,Van Vlieg, Johan E. T. Hylckama,Tang, Lixia,Janssen, Dick B.,Kellogg, Richard M.
, p. 41 - 43 (2007/10/03)
(equation presented) The halohydrin dehalogenase from Agrobacterium radiobacter AD1 catalyzed the highly enantioselective and β-regioselective azidolysis of (substituted) styrene oxides. By means of kinetic resolutions the remaining epoxide and the formed azido alcohol could be obtained in very high ee. In a large scale conversion, the decrease in yield and selectivity due to the uncatalyzed chemical side reaction could be overcome by slow addition of azide.
