34006-49-0

Basic information

• Product Name: 2-chloro-4-nitroacetophenone
• Synonyms: 2-chloro-1-(4-nitrophenyl)ethanone
• CAS NO: 34006-49-0
• Molecular Formula: C₈H₆ClNO₃
• Molecular Weight: 199.59
• Mol File: 34006-49-0.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 322.1°Cat760mmHg
• Flash Point: 148.6°C
• Appearance: /
• Density: 1.384g/cm³
• Vapor Pressure: 0.000285mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: 2-chloro-4-nitroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-nitroacetophenone(34006-49-0)
• EPA Substance Registry System: 2-chloro-4-nitroacetophenone(34006-49-0)

Safety Data

• Hazardous Substances Data: 34006-49-0(Hazardous Substances Data)

Usage

Uses

4-Nitrophenacyl Chloride is a reagent in the preparation of tetrahydropyrrolo[3,2-c]azepin-4-ones as cytotoxic compounds.

InChI:InChI=1/C8H6ClNO3/c9-5-8(11)6-1-3-7(4-2-6)10(12)13/h1-4H,5H2

Upstream product

• 73805-24-0 α-chloro-p-nitrostyrene oxide 
• 4203-31-0 2-diazo-1-(4-nitrophenyl)ethanone 
• 67-56-1 methanol 
• 100-19-6 (4-nitrophenyl)ethanone 
• 6531-13-1 1-[4-nitrophenyl]-1-ethanol 
• 100-13-0 4-nitrostyrene 
• 80-11-5 N-methyl-N-nitrosotoluene-p-sulfonamide 
• 122-04-3 4-nitro-benzoyl chloride 
• 110944-98-4 2-iodo-1-(4-nitrophenyl)ethanone 
• 54075-25-1 4-nitro-α-(trichloromethyl)benzyl alcohol 
• 99-81-0 4-Nitrophenacyl bromide 
• 186581-53-3 diazomethane 
• 60-29-7 diethyl ether 

Downstream Products

• 65921-30-4 2-(4-nitrophenyl)-2-oxoethyl acetate 
• 62625-61-0 5-(4-nitro-phenyl)-2-phenyl-6H-[1,3,4]thiadiazine 
• 62625-68-7 2-benzyl-5-(4-nitro-phenyl)-6H-[1,3,4]thiadiazine 
• 91088-16-3 N,N-Dimethyl-dithiocarbaminsaeure-(4-nitro)-phenacylester 
• 92108-98-0 N,N-Diethyl-dithiocarbaminsaeure-(4-nitro)-phenacylester 
• 97661-33-1 2-methyl-3-{[4-(4-nitro-phenyl)-thiazol-2-yl]-hydrazono}-cyclopentanecarboxylic acid 
• 91556-55-7 Thiophosphorsaeure- 
• 98032-59-8 2-ethyl-3-{[4-(4-nitro-phenyl)-thiazol-2-yl]-hydrazono}-cyclopentanecarboxylic acid 
• 90972-37-5 Dithiophosphorsaeure- 
• 58881-57-5 1-(4-nitrophenyl)-2-[2-(4-nitrophenyl)-2-oxoethylsulfanyl]ethanone 
• 58585-12-9 (3-hydroxybenzo[b]thiophen-2-yl)(4-nitrophenyl)methanone 
• 102183-91-5 4-(4-nitrophenyl)-N-phenyl-1,3-thiazol-2-amine 
• 102183-93-7 2-imino-4-(4-nitrophenyl)-3-phenyl-2,3-dihydrothiazole 
• 109513-41-9 1,3-dimethyl-7-[2-(4-nitro-phenyl)-2-oxo-ethyl]-3,7-dihydro-purine-2,6-dione 

Relevant articles and documents

Solvent-free preparation of α,α-dichloroketones with sulfuryl chloride

An efficient and facile method is reported for the synthesis of a series of α,α-dichloroketones. The direct dichlorination of methyl ketones and 1,3-dicarbonyls using an excess amount of sulfuryl chloride affords the corresponding gem-dichloro compounds in moderate to excellent yields. Moreover, the protocol features high yields, broad substrate scope, and simple reaction conditions without using any catalysts and solvents.

Facile Synthesis of α-Haloketones by Aerobic Oxidation of Olefins Using KX as Nonhazardous Halogen Source

An operationally simple and safe synthesis of α-haloketones using KBr and KCl as nonhazardous halogen sources is reported. It involves an iron-catalysed reaction of alkenes with KBr/KCl using O2 as terminal oxidant under the irradiation of visible-light. This strategy avoids the risks associated with handling halo-contained electrophiles (Cl2, Br2, NCS, NBS). The process is tolerant to several functional groups, and extended to a range of substituted styrenes in up to 89% yield. A radical reaction pathway is proposed based on control experiments and spectroscopy studies.

Facile and efficient preparation of α-halomethyl ketones from α-diazo ketones catalyzed by iron(III) halides and silica gel

An efficient and mild method for the synthesis of α-halomethyl ketones from α-diazo ketones was developed using ferric chloride or bromide as the halogen source and silica gel as the hydrogen source, with good to excellent yields.