325968-64-7

Upstream product

• 261512-59-8 2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneethane-thioamide 
• 219981-44-9 1,1-dimethylethyl α-bromo-β-oxo-benzenepropionate 
• 261512-47-4 2,6-dichloro-α,α-dimethyl-4-nitrobenzeneacetonitrile 
• 261512-58-7 2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-α,α-dimethylbenzeneacetonitrile 
• 261512-57-6 2-[3,5-dichloro-4-(1-cyano-1-methylethyl)phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carboxylic acid 
• 261512-56-5 diethyl N,N'-[2-[[3,5-dichloro-4-(1-cyano-1-methylethyl)phenyl]hydrazono]-1,3-dioxo-1,3-propanediyl]dicarbamate 
• 54441-66-6 tert-butyl benzoylacetate 
• 261512-48-5 4-amino-2,6-dichloro-α,α-dimethylbenzeneacetonitrile 

Downstream Products

• 325968-65-8 2-{1-[2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-phenyl]-1-methyl-ethyl}-4-phenyl-thiazole-5-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 1,2,4- triazinylphenylalkylthiazolecarboxylic acid esters as cytokine-inhibiting antedrugs with strong bronchodilating effects in an animal model of asthma

The influx of leukocytes (eosinophils, lymphocytes, and monocytes) into the airways and their production of proinflammatory cytokines contribute to the severity of allergic asthma. We describe here the synthesis and pharmacological evaluation of a series