3261-89-0

Basic information

• Product Name: 2-(4-methoxyphenyl)-4-oxo-4-phenylbutanenitrile
• CAS NO: 3261-89-0
• Molecular Formula: C₁₇H₁₅NO₂
• Molecular Weight: 265.3065
• Mol File: 3261-89-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 465.3°C at 760 mmHg
• Flash Point: 202.7°C
• Density: 1.139g/cm³
• Vapor Pressure: 7.77E-09mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 2-(4-methoxyphenyl)-4-oxo-4-phenylbutanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-4-oxo-4-phenylbutanenitrile(3261-89-0)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-4-oxo-4-phenylbutanenitrile(3261-89-0)

Safety Data

• Hazardous Substances Data: 3261-89-0(Hazardous Substances Data)

Usage

General Description

The chemical 2-(4-methoxyphenyl)-4-oxo-4-phenylbutanenitrile, also known as methoxyphenylbutanenitrile, is a compound with the molecular formula C17H15NO2. It is a nitrile derivative with a butanenitrile backbone, substituted with a methoxyphenyl and a phenyl group. This chemical is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It has potential applications in the production of drugs and agrochemicals due to its versatile reactivity and pharmacological properties. As a nitrile compound, it is important to handle it with caution and ensure proper safety measures are in place during its handling and synthesis.

Upstream product

• 33646-40-1 4-methoxymandelonitrile 
• 98-86-2 acetophenone 
• 20102-12-9 2-hydroxy-2-phenylpropionitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 
• 22252-15-9 trans-4-methoxychalcone 
• 109-77-3 malononitrile 
• 613-90-1 benzoyl cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 

Downstream Products

• 24737-95-9 4-(4-methoxyphenyl)-6-phenyl-4,5-dihydropyridazin-3(2H)-one 
• 23073-05-4 2-(4-methoxy-phenyl)-4-oxo-4-phenyl-butyric acid methyl ester 
• 3261-90-3 2-(4-methoxyphenyl)-4-oxo-4-phenylbutanoic acid 

Relevant articles and documents

Cyano-borrowing reaction: Nickel-catalyzed direct conversion of cyanohydrins and aldehydes/ketones to β-cyano ketone

A direct nickel-catalyzed, high atom- and step-economical reaction of cyanohydrins with aldehydes or ketones via an unprecedented "cyano-borrowing reaction" has been developed. Cleavage of the C-CN bond of cyanohydrins followed by aldol condensation and conjugate addition of cyanide to α,β-unsaturated ketones proceeded to deliver a range of racemic β-cyano ketones with good to high yields. The practical procedure with the use of a commercial and less-toxic CN source bodes well for wide application of this protocol.

Synthesis of β-Cyano Ketones Promoted by a Heterogeneous Fluoride Catalyst

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Conjugate hydrocyanation of aromatic enones using potassium hexacyanoferrate(II) as an eco-friendly cyanide source

A selective conjugate hydrocyanation of aromatic enones by a one-pot, two-step procedure using potassium hexacyanoferrate(II) as an original eco-friendly cyanide source, potassium hydroxide as a base, and benzoyl chloride as a promoter was described. This protocol has the advantages of a nontoxic cyanide source, high yield, and simple workup procedure. Georg Thieme Verlag Stuttgart · New York.