32682-99-8

Usage

Heterocyclic compound

Imidazole is a five-membered ring structure with 2 nitrogen atoms This makes the compound a heterocyclic aromatic compound, which is a type of organic compound with a ring structure containing at least one heteroatom.

Methyl ester

The carboxylic acid group is esterified with a methyl group This means that the compound has an ester functional group (R-COO-R') derived from the reaction of a carboxylic acid and an alcohol, in this case, methanol.

Derivative of imidazole

The compound is derived from imidazole This indicates that the compound is a modified version of the parent molecule, imidazole, which is a common structural motif in many biologically active molecules.

Potential pharmaceutical applications

The compound may be used in the development of drugs and therapeutic agents This suggests that the compound has properties that could be beneficial in treating diseases or medical conditions.

Use in organic synthesis and chemical research

The compound can be used as a building block or reagent in the synthesis of other organic compounds This means that the compound can be used to create new molecules with various applications.

Hazardous effects

Caution should be taken with 1H-Imidazole-4-carboxylic acid, 2-phenyl-, methyl ester as it may have hazardous effects if mishandled or improperly used This indicates that the compound can pose risks to human health or the environment if not handled or used correctly.

Upstream product

• 97602-43-2 methyl (Z)-3-(5-phenyltetrazol-1-yl)propenoate 
• 97602-42-1 methyl (E)-3-(5-phenyltetrazol-1-yl)propenoate 
• 1181818-57-4 C₁₁H₁₂N₂O₂ 
• 613-92-3 N-hydroxybenzamidine 
• 922-67-8 propynoic acid methyl ester 
• 33469-36-2 2-phenyl-5-(trifluoromethyl)-1H-imidazole 
• 67-56-1 methanol 
• 100-52-7 benzaldehyde 
• 77498-98-7 2-phenyl-1H-imidazole-4-carboxylic acid 
• 32682-97-6 methyl 3-{[(amino(phenyl)methylene)amino]oxy}acrylate 
• 613-92-3 N-hydroxybenzenecarboximidamide 

Downstream Products

• 746671-41-0 methyl 1-methyl-2-phenyl-1H-imidazole-4-carboxylate 
• 235789-66-9 methyl 1-(4-amino-3-methylphenyl)-2-phenylimidazole-4-carboxylate 
• 235789-70-5 methyl 5-chloro-1-(3-methylphenyl)-2-phenylimidazole-4-carboxylate 
• 235789-65-8 methyl 1-(4-aminophenyl)-2-phenylimidazole-4-carboxylate 
• 235789-68-1 methyl 1-(3-methylphenyl)-2-phenylimidazole-4-carboxylate 
• 235789-69-2 methyl 5-chloro-1,2-diphenylimidazole-4-carboxylate 
• 235789-67-0 methyl 1,2-diphenylimidazole-4-carboxylate 
• 235789-64-7 methyl 1-(3-methyl-4-nitrophenyl)-2-phenylimidazole-4-carboxylate 
• 235789-63-6 methyl 1-(4-nitrophenyl)-2-phenylimidazole-4-carboxylate 

Relevant academic research and scientific papers

PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF

The present disclosure provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled compounds, and prodrugs thereof. The provided compounds may be tumor necrosis factor ("TNF") receptor associated protein 1 ("TRAP1") modulators (e.g., TRAP1 activators). The provided compounds may also rescue the activity in PTEN-induced kinase 1 ("PINK1") loss of function contexts. The provided compounds may also improve mitochondrial health, function, quality, quantity, and/or activity, and/or reduce the production of reactive oxygen species. The provided compounds may also refold or solubilize aggregated or misfolded proteins such as a-synuclein. The present disclosure also provides pharmaceutical compositions comprising the provided compounds; kits comprising the provided compounds or pharmaceutical compositions; and methods of using the provided compounds and pharmaceutical compositions (e.g., for treating a disease in a subject in need thereof).

Synthesis of 2,4-Disubstituted Imidazoles via Nucleophilic Catalysis

A convergent, microwave-assisted protocol for the synthesis of disubstituted NH-imidazoles via nucleophilic catalysis is described. The substituted imidazoles are accessed via the intramolecular addition of a variety of amidoxime substrates to activated a

HETEROARYL INHIBITORS OF PAD4

The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.

Highly efficient oxidation of 2-imidazoline-5-carboxylic derivatives to imidazole-5-carboxylic derivatives by dioxygen

A highly efficient and environmental-benign oxidation by dioxygen (or air) as the sole oxidant was first applied for the conversion of 2-imidazoline-5- carboxylic derivatives to imidazole-5-carboxylic derivatives in very good and excellent yields. The sub

PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF

A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I) wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.

Design and synthesis of optically active 2-phenylimidazolecarboxamides featuring amino acid motive

(Chemical Equation Presented) Overall sixteen new, optically active carboxamides 1-3 have been synthesized. These compounds based on the 2-phenylimidazole and featuring amino acid residues are linked on the 4-position by an amidic bond. Two general methods were used for their construction. Whereas the first method employs acylchlorides as a reactive species, the second one involves a condensation of mixed anhydrides with the amino acid counterparts. Actually, the second method proved to be more efficient than the first one. Carboxamides 1-3 were preliminarily tested as N-chelating ligands with an application in the Henry or Aldol reactions affording either poor yields or enantiomeric excesses.

Two-step Synthesis of Imidazoles from Activated Alkynes

Conjugate addition of 2-(tri-n-butylstannyl)tetrazoles (1) to activated alkynes gives 1-alkenyltetrazoles (4) and (5) predominantly.Use of the N-tributylstannyl derivatives, rather than the parent tetrazole, gives a high ratio of 1- to 2-alkenyl isomers and avoids the complication of further addition of the tetrazole or the alkyne to the initial adduct.Irradiation of the (Z)- and (E)-1-alkenyltetrazoles (4) and (5) at 254 nm then gives the expected imidazoles in moderate yield.However, 5-phenyl-2-(tri-n-butylstannyl)tetrazole (1a) reacted only slowly with ethyl phenylpropiolate to give ethyl 3,5-diphenylpyrazole-4-carboxylate (8), presumably via the 2-alkenyltetrazole (9) formed in preference to the 1-isomer for steric reasons.