Welcome to LookChem.com Sign In|Join Free

CAS

  • or

32746-79-5

Post Buying Request

32746-79-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

32746-79-5 Usage

Uses

D-Mannono-1,5-lactone is an intermediate used in the synthesis of Dapagliflozin C2 Epimer (D185405), which is an intermediate used in the synthesis of Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.

Check Digit Verification of cas no

The CAS Registry Mumber 32746-79-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,7,4 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 32746-79:
(7*3)+(6*2)+(5*7)+(4*4)+(3*6)+(2*7)+(1*9)=125
125 % 10 = 5
So 32746-79-5 is a valid CAS Registry Number.

32746-79-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name δ-D-mannononolactone

1.2 Other means of identification

Product number -
Other names δ-D-mannonolactone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:32746-79-5 SDS

32746-79-5Synthetic route

mannonic acid
642-99-9

mannonic acid

A

D-mannono-1,4-lactone
26301-79-1

D-mannono-1,4-lactone

B

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

Conditions
ConditionsYield
With water at 25℃;
With 1,4-dioxane Eindampfen unter vermindertem Druck;
D-Mannose
530-26-7

D-Mannose

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

Conditions
ConditionsYield
With N-Bromosuccinimide; sulfuric acid; mercury(II) diacetate In water; acetic acid at 26.9℃; Kinetics; Thermodynamic data; Mechanism; further temperatures, also with Ru(III) as a catalyst; ΔG(excit.), ΔS(excit.), ΔH(excit.), Ea;
With silver nitrate at 80 - 130℃; Thermodynamic data; Rate constant; Equilibrium constant; pH 1, other oxidants, DΕ excit, DΣ excit, DΦ, DΗ;
With potassium dichromate; perchloric acid In water at 60℃; for 1h; Kinetics; Activation energy; Further Variations:; Reagents; Catalysts; Temperatures; Solvents;
With bromine; barium carbonate In water
sodium-mannonate

sodium-mannonate

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

Conditions
ConditionsYield
With acetic acid
aqueous d-mannonic acid-solution

aqueous d-mannonic acid-solution

A

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

B

γ lactone

γ lactone

Conditions
ConditionsYield
at 50 - 90℃; under 15 Torr; beim Eindampfen;
D-Mannose
530-26-7

D-Mannose

A

D-mannono-1,4-lactone
26301-79-1

D-mannono-1,4-lactone

B

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

Conditions
ConditionsYield
[(C4Ph4CO)(CO)2Ru]2 In cyclohexanone; N,N-dimethyl-formamide at 21℃; for 87h; Title compound not separated from byproducts;
D-Mannose
3458-28-4

D-Mannose

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

Conditions
ConditionsYield
With quinoprotein D-glucose dehydrogenase Enzymatic reaction;
C20H18N2O

C20H18N2O

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

N-D-mannonyl-N'-1-pyrenemethyl-β-alaninamide

N-D-mannonyl-N'-1-pyrenemethyl-β-alaninamide

Conditions
ConditionsYield
In methanol for 6h; Heating;67.2%
C20H18N2O

C20H18N2O

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

N-D-mannonyl-N'-1-pyrenemethyl-L-alaninamide

N-D-mannonyl-N'-1-pyrenemethyl-L-alaninamide

Conditions
ConditionsYield
In methanol for 6h; Heating;65%
C19H16N2O

C19H16N2O

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

N-D-mannonyl-N'-1-pyrenemethylglycinamide

N-D-mannonyl-N'-1-pyrenemethylglycinamide

Conditions
ConditionsYield
In methanol for 6h; Heating;58%
C20H18N2O

C20H18N2O

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

N-D-mannonyl-N'-1-pyrenemethyl-D-alaninamide

N-D-mannonyl-N'-1-pyrenemethyl-D-alaninamide

Conditions
ConditionsYield
In methanol for 6h; Heating;56%
acetic anhydride
108-24-7

acetic anhydride

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

2,3,4,6-tetra-O-acetyl-D-mannono-1,5-lactone
61259-48-1, 73322-42-6

2,3,4,6-tetra-O-acetyl-D-mannono-1,5-lactone

Conditions
ConditionsYield
With hydrogenchloride
δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

fructonic acid
669-90-9

fructonic acid

Conditions
ConditionsYield
With iron(III) sulfate; water; calcium carbonate und Chrom(VI)-oxid;
δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

D-mannono-1,4-lactone
26301-79-1

D-mannono-1,4-lactone

Conditions
ConditionsYield
With water at 100℃;
1-(Trimethylsilyl)imidazole
18156-74-6

1-(Trimethylsilyl)imidazole

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

trimethylsilyl ether of mannono-1,5-lactone
32469-28-6

trimethylsilyl ether of mannono-1,5-lactone

Conditions
ConditionsYield
With pyridine hydrochloride In various solvent(s)
methanol
67-56-1

methanol

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

methyl 3,4:5,6-di-O-isopropylidene-D-gluconate
114743-85-0

methyl 3,4:5,6-di-O-isopropylidene-D-gluconate

Conditions
ConditionsYield
With methanesulfonic acid In acetone for 48h; Ambient temperature; Yield given;
δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

methyl iodide
74-88-4

methyl iodide

silver oxide

silver oxide

O2,O3,O5,O6-tetramethyl-D-mannonic acid-lactone
20869-29-8

O2,O3,O5,O6-tetramethyl-D-mannonic acid-lactone

Conditions
ConditionsYield
erst in Methanol, dann in Aceton;
δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

(4R,5S)-4-Amino-5-((R)-1,2-dihydroxy-ethyl)-dihydro-furan-2-one; hydrobromide

(4R,5S)-4-Amino-5-((R)-1,2-dihydroxy-ethyl)-dihydro-furan-2-one; hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: MsOH / acetone / 48 h / Ambient temperature
2: pyridine / 1.) 0 deg C, 1 h, 2.) r.t., 1 h
3: 46 percent / aq. ammonia / 120 h
4: 100 percent / N2H4 / H2O / 2 h / Heating
5: TFA, H2O / 1 h / Ambient temperature
6: Br2 / H2O
View Scheme
δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

(3R,4S,5R)-3-Amino-4,5,6-trihydroxy-hexanoic acid hydrazide

(3R,4S,5R)-3-Amino-4,5,6-trihydroxy-hexanoic acid hydrazide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: MsOH / acetone / 48 h / Ambient temperature
2: pyridine / 1.) 0 deg C, 1 h, 2.) r.t., 1 h
3: 46 percent / aq. ammonia / 120 h
4: 100 percent / N2H4 / H2O / 2 h / Heating
5: TFA, H2O / 1 h / Ambient temperature
View Scheme
δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

(2R,3R)-3-[(S)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-aziridine-2-carboxylic acid amide
204059-79-0

(2R,3R)-3-[(S)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-aziridine-2-carboxylic acid amide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: MsOH / acetone / 48 h / Ambient temperature
2: pyridine / 1.) 0 deg C, 1 h, 2.) r.t., 1 h
3: 46 percent / aq. ammonia / 120 h
View Scheme
δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

(3R,4S)-3-Amino-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-hydroxy-butyric acid hydrazide
204059-86-9

(3R,4S)-3-Amino-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-hydroxy-butyric acid hydrazide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: MsOH / acetone / 48 h / Ambient temperature
2: pyridine / 1.) 0 deg C, 1 h, 2.) r.t., 1 h
3: 46 percent / aq. ammonia / 120 h
4: 100 percent / N2H4 / H2O / 2 h / Heating
View Scheme
δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

(R)-Methanesulfonyloxy-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-acetic acid methyl ester
117462-56-3

(R)-Methanesulfonyloxy-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-acetic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: MsOH / acetone / 48 h / Ambient temperature
2: pyridine / 1.) 0 deg C, 1 h, 2.) r.t., 1 h
View Scheme
δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

(2R,3R)-3-[(S)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-1-(toluene-4-sulfonyl)-aziridine-2-carboxylic acid amide

(2R,3R)-3-[(S)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-1-(toluene-4-sulfonyl)-aziridine-2-carboxylic acid amide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: MsOH / acetone / 48 h / Ambient temperature
2: pyridine / 1.) 0 deg C, 1 h, 2.) r.t., 1 h
3: 46 percent / aq. ammonia / 120 h
4: 37 percent / pyridine / 2 h / 0 °C
View Scheme
δ-D-mannonolactone
32746-79-5

δ-D-mannonolactone

2,6-Dibromo-2,6-dideoxy-D-glucono-1,4-lactone
78138-23-5

2,6-Dibromo-2,6-dideoxy-D-glucono-1,4-lactone

Conditions
ConditionsYield
With hydrogen bromide; acetic acid In water at 20℃; for 4h;4.6 g

32746-79-5Relevant articles and documents

Enantioselective and protecting group-free synthesis of 1-deoxythionojirimycin, 1-deoxythiomannojirimycin, and 1- deoxythiotalonojirimycin

Gunasundari, Thanikachalam,Chandrasekaran, Srinivasan

supporting information; experimental part, p. 6685 - 6688 (2010/12/25)

1-Deoxythioglyconojirimycins were synthesized by using a protecting group-free strategy, starting from readily available carbohydrates, in good overall yield. Use of benzyltriethylammonium tetrathiomolybdate, [BnEt 3N]2MoS4, as a sulfur transfer reagent and borohydride exchange resin (BER) reduction of a lactone enabled the efficient synthesis of the title compounds.

δ-Galactonolactone: Synthesis, isolation, and comparative structure and stability analysis of an elusive sugar derivative

Bierenstiel, Matthias,Schlaf, Marcel

, p. 1474 - 1481 (2007/10/03)

δ-D-Gluconolactone, δ-D-mannonolactone, and - for the first time - the thermodynamically unstable δ-D-galactonolactone have been prepared and isolated from DMF solution by oxidizing the corresponding sugars with Shvo's catalyst [(C4Ph4CO)(CO)2Ru] 2 and a hydrogen acceptor. The preferred conformation of δ-D-galactonolactone in [D6] DMSO solution has been determined by 1H NMR spectroscopy experiments and DFT calculations to be 4H3 and is compared to those of the previously established conformations of δ-D-gluconolactone (4H3) and δ-D-mannonolactone (B2,5), The conformations of the lactones suggest an explanation for their relative rates of isomerization to their respective γ-D-lactones by an intramolecular mechanism. Wiley-VCH Verlag GmbH & Co, KGaA, 69451 Weinheim, Germany, 2004.

Kinetics of Ru(III) Catalysed Oxidation of Aldoses by N-Bromosuccinimide in Aqueous Acetic Acid

Kistayya, T.,Reddy, M. Surekha,Kandlikar, Sushama

, p. 905 - 907 (2007/10/02)

The title reaction, studied in the presence of mercuric acetate, sulphuric acid and 10percent (v/v) acetic acid, is first order in both in the presence and absence of catalyst.However, the order in in the absence of catalyst, Ru(III) is unity which changes to fractional order in the presence of it.Increase in retards the reaction rate.The order of reactivities of different aldoses is: D-arabinose > D-xylose > D-galactose > D-mannose > D-glucose.Individual rate constants (k), formation constants (K) of the complex of aldoses and the catalyst and corresponding thermodynamic parameters have been evaluated and a suitable mechanism involving the α-anomer of aldose as the reactive substrate species has been suggested.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 32746-79-5