327618-31-5

Usage

Benzooxazole derivative

This indicates that the compound is derived from benzoxazole, a five-membered heterocyclic aromatic ring system.

Tetrahydrofuran group attached to the benzene ring

This describes the structure of the compound, indicating that a tetrahydrofuran group (a cyclic ether with four carbon atoms) is attached to the benzene ring of the benzoxazole.

Potential applications in drug discovery and pharmaceuticals

This suggests that the compound has potential for use in the development of new drugs and in the pharmaceutical industry.

Unique structure and potential biological activities

This indicates that the compound has a distinctive structure and may have biological effects that could be useful in drug development.

Should be handled with care and used in a controlled laboratory setting

This is a safety precaution, indicating that the compound may have potential hazards associated with its handling and use.

Upstream product

• 109-99-9 tetrahydrofuran 
• 615-18-9 2-chloro-1,3-benzoxazole 
• 95-55-6 2-amino-phenol 
• 2843-27-8 N-(2-hydroxyphenyl)formamide 
• 1355021-17-8 2-isocyano-1-(2-tetrahydrofuranyloxy)benzene 
• 1355021-61-2 N-(2-(2-tetrahydrofuranyloxy)phenyl)formamide 
• 273-53-0 benzoxazole 
• 91749-29-0 2-(methylsulfonyl)benzo[d]oxazole 

Relevant academic research and scientific papers

Aryl Ketone Mediated Photoinduced Radical Coupling for the Alkylation?-of Benzazoles Employing Saturated Heterocyclic Compounds?

An aryl ketone mediated synthesis of 2-alkylated benzazoles was achieved via radical coupling under photoirradiation starting from saturated heterocycles and 2-sulfonylated benzazoles, such as benzothiazoles, benzoxazole, and benzimidazole. Heterocyclic compounds, including a cyclic ether, azacycles, and tetrahydrothiophene, were applicable, and the benzazole unit was site-selectively installed at the carbon center proximal to the heteroatom. The present transformation takes place at ambient temperature under neutral reaction conditions without the aid of any metallic catalysts or reagents.

Method for preparing N-heterocyclic aromatic hydrocarbon derivatives by dehalogenation and alkylation

The invention discloses a method for preparing N-heterocyclic aromatic hydrocarbon derivatives by dehalogenation and alkylation. The method includes: dissolving halogenated N-heterocyclic aromatic hydrocarbon compounds, ether compounds, copper salts, an N-F reagent and protonic acid into an organic solvent, stirring in oil bath, performing reaction for 3-20h at a temperature of 20-60 DEG C, and after reaction is finished, treating reaction liquid to obtain the N-heterocyclic aromatic hydrocarbon derivatives. The method has advantages that dehalogenation and alkylation of the N-heterocyclic aromatic hydrocarbon compounds are realized under catalysis of the copper salts, high regioselectivity in reaction is achieved, a reaction substrate application range is expanded, and selective dehalogenation and alkylation of halogenated heterocyclic aromatic hydrocarbon compounds such as halogenated quinoline derivatives, halogenated isoquinoline derivatives, halogenated benzoxazole derivatives andhalogenated benzothiazole derivatives can be realized.

Heterogeneous Co-catalyzed direct 2-alkylation of azoles with ethers

The direct 2-alkylation of oxazoles and thiazoles with ethers through cross-dehydrogenative coupling reaction using Co-containing mesoporous zeolite ETS-10 as the heterogeneous catalyst is described. The basic Co-containing mesoporous zeolite ETS-10 catal

Sunflow: Sunlight Drives Fast and Green Photochemical Flow Reactions in Simple Microcapillary Reactors – Application to Photoredox and H-Atom-Transfer Chemistry

“Sunflow“ – The combination of a microcapillary reactor in continuous flow mode with sunlight as the most sustainable energy source imaginable was applied to a range of photoredox and H-atom-transfer reactions making them both fast and green.

Light Induced C-C Coupling of 2-Chlorobenzazoles with Carbamates, Alcohols, and Ethers

A light induced, transition-metal-free C-C coupling reaction of 2-chlorobenzazoles with aliphatic carbamates, alcohols, and ethers is presented. Inexpensive reagents, namely sodium acetate, benzophenone, water, and acetonitrile, are employed in a simple reaction protocol using a cheap and widely available 25 W energy saving UV-A lamp at ambient temperature.

Iron-catalyzed direct α-arylation of ethers with azoles

The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process. This practical oxidative method allowed the efficient C2-alkylation of a variety of (ben

Tandem migration - Carboalkoxylation of o-isocyanophenyl acetals leading to benzoxazoles

An efficient approach to benzoxazoles via tandem migration - carboalkoxylation of o-isocyanophenyl acetals has been developed. Both a Lewis acid and base are essential for this reaction, and the BF3· OEt2/2,4,6-collidine combination

Direct C2-alkylation of azoles with alcohols and ethers through dehydrogenative cross-coupling under metal-free conditions

A metal-free novel, simple, and highly efficient method for the direct C2-alkylation of azoles with alcohols and ethers has been developed on the basis of an oxidative C-H activation process. The dehydrogenative C-C cross-coupling reactions of R-position