32772-86-4

Upstream product

• 60-35-5 acetamide 
• 21368-28-5 4-chlorobenzoyl azide 
• 13463-94-0 N-(4-chlorophenyl)cyanamide 
• 108-24-7 acetic anhydride 
• 3955-50-8 N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl) urea 
• 75-36-5 acetyl chloride 
• 140-38-5 N-(4-chlorophenyl)urea 
• 104-12-1 p-chlorphenylisocyanate 
• 10416-59-8 (Z)-trimethylsilyl N-trimethylsilylacetimidate 
• 1219-99-4 N,N'-bis(4-chlorophenyl)urea 
• 619-56-7 4-chlorobenzamide 

Relevant academic research and scientific papers

In situ slow release of isocyanates: Synthesis and organocatalytic application of N-acylureas

A novel, efficient, and operationally simple one-pot synthesis of both, symmetrical and unsymmetrical N-acylureas from carboxamides and in situ generated isocyanates (from N,N-dibromo-p-toluenesulfonamide) in the presence of a mild base at rt is reported. The protocol avoids the tedious isolation and purification steps of hazardous isocyanates. The first application of these acylureas to the catalysis through hydrogen bonding is also demonstrated.

REACTIONS OF ISOTHIOCYANATES AND ISOCYANATES WITH SOME SILYLATED NITROGEN-CONTAINING NUCLEOPHILES

Aryl isothiocyanates and arylisocyanates react with N,O-bis(trimethylsilyl)acetamide to give N-methyl-N'-arylthioureas and ureas.Also nucleophilic additions of other aprotic nucleophiles (e.g.N-trimethylsilylimidazole, N-trimethylsilylpiperidine and N-trimethylsilylmorpholine) to the N=C=X (X=O,S) group were investigated.