328040-18-2

Upstream product

• 50541-93-0 4-amino-1-benzylpiperidine 
• 109-70-6 1.3-chlorobromopropane 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 14753-26-5 3-chloropropan-1-amine 

Downstream Products

• 328040-19-3 (1-benzyl-piperidin-4-yl)-(3-chloro-propyl)-carbamic acid tert-butyl ester 
• 328040-27-3 4-{[3-(4-benzyloxy-3,5-dimethoxy-benzoylamino)-propyl]-tert-butoxycarbonyl-amino}-piperidine-1-carboxylic acid allyl ester 
• 328040-05-7 4-benzyloxy-N-{3-[1-(2,2-diphenyl-ethyl)-piperidin-4-ylamino]-propyl}-3,5-dimethoxy-benzamide 
• 328040-36-4 [3-(4-benzyloxy-benzylamino)-propyl]-(1-cyclohexanecarbonyl-piperidin-4-yl)-carbamic acid tert-butyl ester 
• 328040-47-7 [3-(4-benzyloxy-3,5-dimethoxy-benzoylamino)-propyl]-piperidin-4-yl-carbamic acid tert-butyl ester 
• 328040-34-2 (3-azido-propyl)-(1-cyclohexanecarbonyl-piperidin-4-yl)-carbamic acid tert-butyl ester 
• 328040-33-1 (3-chloro-propyl)-(1-cyclohexanecarbonyl-piperidin-4-yl)-carbamic acid tert-butyl ester 
• 328040-35-3 (3-amino-propyl)-(1-cyclohexanecarbonyl-piperidin-4-yl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Potent 4-aminopiperidine based antimalarial agents

This paper describes potent antimalarial compounds effective against a multi-drug-resistant strain of P. falciparum (Dd2) with minimized toxicity, acceptable log D values, and stability to hepatocytic metabolism. A series of compounds with potent activity

Novel and potent anti-malarial agents

Readily accessible, novel, and potent anti-malarial compounds have been developed. Optimization of the initial lead structure resulted in derivatives with IC50 values from 7 to 35 nM against chloroquine-sensitive and 70-350 nM against chloroquine-resistant strains of Plasmodium falciparum.