32819-24-2

Usage

Uses

Used in Pharmaceutical Industry:
Diethyl 2-Ethyl-2-acetamidomalonate is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its unique chemical structure allows for the creation of diverse molecules with potential therapeutic applications, addressing various health conditions and medical needs.
Used in Agrochemical Industry:
In the agrochemical sector, Diethyl 2-Ethyl-2-acetamidomalonate is employed as a building block for the synthesis of novel agrochemicals. These synthesized compounds can be used to develop more effective and environmentally friendly pesticides, herbicides, and other agricultural products, enhancing crop protection and yield.
Used in Specialty Chemicals:
Diethyl 2-Ethyl-2-acetamidomalonate is also used as a key component in the synthesis of specialty chemicals. These chemicals find applications in various industries, such as plastics, coatings, and materials science, where they contribute to the development of innovative products with improved properties and performance.
Overall, Diethyl 2-Ethyl-2-acetamidomalonate plays a crucial role in the synthesis of a wide range of organic compounds, making it a valuable asset in the pharmaceutical, agrochemical, and specialty chemicals industries. Its versatility and unique chemical properties enable the development of innovative products that address various challenges and needs across different sectors.

Synthesis Reference(s)

The Journal of Organic Chemistry, 44, p. 3063, 1979 DOI: 10.1021/jo01331a020

Upstream product

• 74-96-4 ethyl bromide 
• 141-52-6 sodium ethanolate 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 75-03-6 ethyl iodide 

Downstream Products

• 2835-81-6 2-aminobutanoic acid 
• 115-70-8 2-ethyl-2-amino-propane-1,3-diol 

Relevant academic research and scientific papers

Synthesis and Antiangiogenic Properties of Tetrafluorophthalimido and Tetrafluorobenzamido Barbituric Acids

The development of novel thalidomide derivatives as immunomodulatory and anti-angiogenic agents has revived over the last two decades. Herein we report the design and synthesis of three chemotypes of barbituric acids derived from the thalidomide structure: phthalimido-, tetrafluorophthalimido-, and tetrafluorobenzamidobarbituric acids. The latter were obtained by a new tandem reaction, including a ring opening and a decarboxylation of the fluorine-activated phthalamic acid intermediates. Thirty compounds of the three chemotypes were evaluated for their anti-angiogenic properties in an ex vivo assay by measuring the decrease in microvessel outgrowth in rat aortic ring explants. Tetrafluorination of the phthalimide moiety in tetrafluorophthalimidobarbituric acids was essential, as all of the nonfluorinated counterparts lost anti-angiogenic activity. An opening of the five-membered ring and the accompanying increased conformational freedom, in case of the corresponding tetrafluorobenzamidobarbituric acids, was well tolerated. Their activity was retained, although their molecular structures differ in torsional flexibility and possible hydrogen-bond networking, as revealed by comparative X-ray crystallographic analyses.

Pd-containing organopolyoxometalates derived from Dawson polyoxometalate [P2W15V3O62]9-: Lewis acidity and dual site catalysis

Grafting of a palladium complex to the Dawson vanadotungstate polyanion [P2W15V3O62]9- via an organic ligand generates a large family of pincer-type hybrid polyoxometalates. The palladium-POM derivatives have dual catalytic properties. Unlike their parent inorganic polyanions, they catalyze allylations while retaining their oxidant character, which leads to single-pot dual site catalysis. This opens a new route for multicatalytic reactions.

Pyrrolizidine alkaloid biosynthesis. Incorporation of 2-aminobutanoic acid labelled with 13C or 2H into the senecic acid portion of rosmarinine and senecionine

(±)-[3,4-13C2]-2-Aminobutanoic acid 10 and (±)-[3,4-2H5]-2-aminobutanoic acid 11 are synthesized by alkylating diethyl acetamidomalonate with labelled ethyl iodide followed by acid hydrolysis. These compounds are used to obtain complete labelling patterns for the first time in a necic acid by studying the pyrrolizidine alkaloids rosmarinine 3 and senecionine 1 using NMR spectroscopy. The senecic acid portion 12 of both alkaloids shows equal incorporation of [3,4-13C2]-2-aminobutanoic acid 10 into the two C5 halves of the C10 acid consistent with formation of senecic acid via two molecules of isoleucine. After feeding [3,4-2H5]-2-aminobutanoic acid 11, retention of 2H at C-13 and C-20 of both alkaloids 13 confirms that the biosynthesis does not involve keto intermediates at these carbon atoms.