115-70-8

Basic information

• Product Name: 2-Amino-2-ethyl-1,3-propanediol
• Synonyms: 2-amino-2-hydroxymethyl-1-butanol;2-Ethyl-2-aminopropanediol;3-Propanediol,2-amino-2-ethyl-1;AEPD;AEPD-85;Aminoethyl propanediol;2-ETHYL-2-AMINO-1 3-PROPANEDIOL;2-AMINO-2-ETHYL-1,3-PROPANEDIOL
• CAS NO: 115-70-8
• Molecular Formula: C₅H₁₃NO₂
• Molecular Weight: 119.16
• EINECS: 204-101-2
• Product Categories: Industrial/Fine Chemicals;API intermediates
• Mol File: 115-70-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 35-37°C
• Boiling Point: 152-153 °C (10 mmHg)
• Flash Point: 152-153°C/10mm
• Appearance: Clear yellow/Viscous Liquid
• Density: 1.099
• Vapor Pressure: 0.000737mmHg at 25°C
• Refractive Index: 1.4851-1.4871
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 12.27±0.20(Predicted)
• Water Solubility: soluble
• Sensitive: Hygroscopic
• Merck: 14,439
• CAS DataBase Reference: 2-Amino-2-ethyl-1,3-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-2-ethyl-1,3-propanediol(115-70-8)
• EPA Substance Registry System: 2-Amino-2-ethyl-1,3-propanediol(115-70-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 41-36/37/38-22
• Safety Statements: 37/39-26-36/37
• TSCA: Yes
• Hazardous Substances Data: 115-70-8(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow viscous liquid

Uses

Different sources of media describe the Uses of 115-70-8 differently. You can refer to the following data:
1. Emulsifying agent (in soap form) for oils, fats, and waxes, absorbent for acidic gases CO 2 and H 2 S, organic synthesis.
2. It is used in pharmaceutical industry and in medicine.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C5H13NO2/c1-2-5(6,3-7)4-8/h7-8H,2-4,6H2,1H3/p+1

Synthetic route

2-nitro-2-ethyl-1,3-propanediol (597-09-1) → 2-ethyl-2-amino-propane-1,3-diol (115-70-8)

Conditions	Yield
With methanol; nickel at 50℃; under 51485.6 Torr; Hydrogenation;
With ethanol; nickel at 20℃; under 36775.4 - 102971 Torr; Hydrogenation;
With phosphoric acid; iron at 100℃;
With sulfuric acid; iron at 100℃;
With propylamine; hydrogen; molybdenum promoted RANEY type nickel catalyst In methanol at 35℃; under 36961.4 Torr; Product distribution / selectivity; Autoclave; Industry scale;

5-amino-5-ethyl-1.3-dioxane → 2-ethyl-2-amino-propane-1,3-diol (115-70-8)

Conditions	Yield
With mineral acid

cyclic acetal of 2-amino-2-ethyl-propanediol-(1.3) → 2-ethyl-2-amino-propane-1,3-diol (115-70-8)

Conditions	Yield
With mineral acid

methanol (67-56-1) + 2-nitro-2-ethyl-1,3-propanediol (597-09-1) + Raney nickel → 2-aminobutanol (96-20-8, 13054-87-0) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8)

Conditions	Yield
Hydrogenation;

C13H25NO4 (1033408-72-8) → 2-ethyl-2-amino-propane-1,3-diol (115-70-8)

Conditions	Yield
With hydrogenchloride In methanol; water at 20℃; Inert atmosphere;

diethyl 2-acetylamino-2-ethylmalonate (32819-24-2) → 2-ethyl-2-amino-propane-1,3-diol (115-70-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere 2: hydrogenchloride; water / methanol / Reflux; Inert atmosphere View Scheme

2-acetamido-2-ethyl-1,3-propanediol (39116-23-9) → 2-ethyl-2-amino-propane-1,3-diol (115-70-8)

Conditions	Yield
With hydrogenchloride; water In methanol Reflux; Inert atmosphere;

ethyl trifluoroacetate, (383-63-1) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → N-(1,1-bis-hydroxymethyl-propyl)-2,2,2-trifluoro-acetamide

Conditions	Yield
	100%

acetic acid (64-19-7) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 2-ammonio-2-ethylpropane-1,3-diol acetate

Conditions	Yield
In chloroform for 0.75h; Ambient temperature;	99%

triisopropylsilyl chloride (13154-24-0) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 6-ethyl-3,3,9,9-tetraisopropyl-2,10-dimethyl-4,8-dioxa-3,9-disilaundecan-6-amine

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 36h; Inert atmosphere;	98%
With triethylamine In dichloromethane at 0 - 20℃; for 36h; Inert atmosphere;	95%
With triethylamine In dichloromethane
With triethylamine In dichloromethane at 20℃;

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → (1,1-bis-(hydroxymethyl)propyl)carbamic acid benzyl ester (1346041-88-0)

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere;	97%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 2-{[1-(2-hydroxy-3-methoxyphenyl)methylidene]amino}-2-ethylpropane-1,3-diol (68322-96-3)

Conditions	Yield
In methanol at 20℃; for 0.333333h;	93%
In methanol Reflux;	81.7%
With triethylamine In methanol for 1h; Reflux;

2,2'-dithiodibenzoic acid dichloride (19602-82-5) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 2,2'-dithiobisbenzamide> (81419-25-2)

Conditions	Yield
In tetrahydrofuran for 2h; Ambient temperature;	90%

salicylaldehyde (90-02-8) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 2-ethyl-2-((2-hydroxybenzylideneamino)propane-1,3-diol)

Conditions	Yield
In methanol at 45℃; for 1h;	90%
In methanol at 50 - 60℃;	87%
In methanol at 85℃; for 8h; Reflux;	85%
In methanol for 1h; Heating;
In methanol for 4h; Reflux;

1,4-dioxane-2,6-dione (4480-83-5) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → polymer; monomer(s): diglycolic anhydride; 2-amino-2-ethyl-1,3-propanediol

Conditions	Yield
at 110℃; for 18h;	90%

2-ethyl-2-amino-propane-1,3-diol (115-70-8) + 4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carbaldehyde (189763-05-1) → 2-[(1,1-bis-hydroxymethyl-propylamino)-methyl]-naphtho[2,3-b]furan-4,9-dione

Conditions	Yield
Stage #1: 2-ethyl-2-amino-propane-1,3-diol; 2-formyl-4,9-dihydronaphtho[2,3-b]-furan-4,9-dione With magnesium sulfate In dichloromethane for 24h; Condensation; Stage #2: With sodium cyanoborohydride; acetic acid In methanol for 0.5h; pH=6 - 7; Reduction;	89%

4-biphenyl isocyanate (92-95-5) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 1-biphenyl-4-yl-3-(1,1-bis(hydroxymethyl)propyl)urea (1346041-33-5)

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 15h; Inert atmosphere;	89%

4-Nitrophenyl isocyanate (100-28-7) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 1-(1,1-bis(hydroxymethyl)propyl)-3-(4-nitrophenyl)urea (1346040-78-5)

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 14h; Inert atmosphere;	89%

succinic acid anhydride (108-30-5) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → polymer; monomer(s): succinic anhydride; 2-amino-2-ethyl-1,3-propanediol

Conditions	Yield
at 130℃; for 45h;	88%

2-ethyl-2-amino-propane-1,3-diol (115-70-8) + 1,2-cis-cyclohexanedicarboxylic anhydride (13149-00-3) → polymer; monomer(s): cis-1,2-cyclohexanedicarboxylic anhydride; 2-amino-2-ethyl-1,3-propanediol

Conditions	Yield
at 125℃; for 29h;	88%

isophorone diisocyanate (4098-71-9) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → hyperbranched poly(urea-urethane) copolymer, polycondensation, degree of branching 56.5 percent, Mw 21970; monomer(s): isophorone diisocyanate; 2-amino-2-ethyl-1,3-propanediol

Conditions	Yield
In N,N-dimethyl acetamide at 60℃; for 150h;	85%

2-ethyl-2-amino-propane-1,3-diol (115-70-8) + di(4-isocyanatophenyl)methane (101-68-8) → hyperbranced poly(urea-urethane) copolymer, polycondensation, degree of branching 44.4 percent, Mw 25450; monomer(s): 4,4\-methylenebis(phenyl isocyanate); 2-amino-2-ethyl-1,3-propanediol

Conditions	Yield
In N,N-dimethyl acetamide at 60℃; for 60h;	85%

glutaric anhydride, (108-55-4) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → polymer; monomer(s): glutaric anhydride; 2-amino-2-ethyl-1,3-propanediol

Conditions	Yield
at 120℃; for 45h;	85%

p-Tolylisocyanate (622-58-2) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 1-(1,1-bis(hydroxymethyl)propyl)-3-p-tolyl-urea (1346041-12-0)

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 13h; Inert atmosphere;	85%

di-tert-butyl dicarbonate (24424-99-5) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 2-((tert-butoxycarbonyl)amino)-2-ethyl-1,3-propanediol (391678-52-7)

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 20h;	84%
With N-ethyl-N,N-diisopropylamine In methanol at 0 - 20℃; for 16.6667h;
With N-ethyl-N,N-diisopropylamine In methanol at 20℃; for 16.6667h; Ice-cooling;

phenyl isocyanate (103-71-9) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 1-(1,1-bis(hydroxymethyl)propyl)-3-phenylurea (1357098-09-9)

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 5h; Inert atmosphere;	84%

C18H14N2O2 + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → C22H23N3O3

Conditions	Yield
With potassium carbonate In dichloromethane; dimethyl sulfoxide Reflux; Inert atmosphere;	84%

2-ethyl-2-amino-propane-1,3-diol (115-70-8) + 5-chlorosalicyclaldehyde (635-93-8) → 2-(5-chloro-2-hydroxybenzylideneamino)-2-ethylpropane-1,3-diol

Conditions	Yield
In methanol for 1h; Reflux;	83%
In methanol for 1h; Heating;
In methanol for 4h; Reflux;

2-ethyl-2-amino-propane-1,3-diol (115-70-8) + 2,6-dimethylphenylisocyanate (28556-81-2) → 1-(2-ethyl-1,3-dihydroxypropan-2-yl)-3-(2,6-dimethylphenyl)urea (1346041-50-6)

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 3h; Inert atmosphere;	83%

2-ethyl-2-amino-propane-1,3-diol (115-70-8) + 2,4-Toluene diisocyanate (584-84-9) → hyperbranced poly(urea-urethane) copolymer, polycondensation, degree of branching 43.8 percent, Mw 19450; monomer(s): toluene-2,4-diisocyanate; 2-amino-2-ethyl-1,3-propanediol

Conditions	Yield
In N,N-dimethyl acetamide at 60℃; for 60h;	81%

2-ethyl-2-amino-propane-1,3-diol (115-70-8) + Diethyl carbonate (105-58-8) → 4-Ethyl-4-(hydroxymethyl)-2-oxazolidinone (162632-59-9)

Conditions	Yield
With sodium methylate at 109.85℃; for 24h;	80%
With sodium methylate In ethyl acetate	80%
With sodium methylate In ethyl acetate	80%

bis(acetylacetonato)dioxomolybdenum(VI) + salicylaldehyde (90-02-8) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → MoO2(2+)*C6H4(O)CHNC(C2H5)(CH2O)CH2OH(2-)*CH3OH=MoO2(C6H4(O)CHNC(C2H5)(CH2O)CH2OH)(CH3OH) (168099-60-3)

Conditions	Yield
With MeOH In methanol equimolar amts.; refluxing aldehyde with amine for 1 h, cooling, addn. of Mo-compd. (stirring), refluxing for 2 h; cooling, pptn. on slow evapn. in air (several d); elem. anal.;	80%

C24H16N2O2 (1452783-09-3) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → C28H25N3O3 (1452783-13-9)

Conditions	Yield
With potassium carbonate In dichloromethane; dimethyl sulfoxide Inert atmosphere; Schlenk technique; Reflux;	80%

ortho-toluoyl chloride (933-88-0) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 2-methyl-N-(1,3-dihydroxy-2-ethylpropan-2-yl)benzamide

Conditions	Yield
With triethylamine In isopropyl alcohol at 0 - 20℃;	80%

2-ethyl-2-amino-propane-1,3-diol (115-70-8) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → 2-ethyl-2-[(2-hydroxynaphthalene-1-yl)methyleneamino]propane-1,3-diol (1415911-94-2)

Conditions	Yield
In methanol for 4h; Reflux;	78%
In methanol at 50 - 60℃;
In methanol for 1h; Reflux;

ethyl 1-imidazolecarboxylate (19213-72-0) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 4-Ethyl-4-(hydroxymethyl)-2-oxazolidinone (162632-59-9)

Conditions	Yield
With potassium carbonate In tetrahydrofuran for 15h; Reflux;	78%

2-hydroxy-5-methylbenzaldehyde (613-84-3) + 2-ethyl-2-amino-propane-1,3-diol (115-70-8) → 2-ethyl-2-{[1-(2-hydroxy-5-methylphenyl)methylidene]amino}propane-1,3-diol

Conditions	Yield
In methanol for 0.5h; Reflux;	78%

Upstream product

• 67-56-1 methanol 
• 597-09-1 2-nitro-2-ethyl-1,3-propanediol 
• 32819-24-2 diethyl 2-acetylamino-2-ethylmalonate 
• 39116-23-9 2-acetamido-2-ethyl-1,3-propanediol 
• 1033408-72-8 C₁₃H₂₅NO₄ 

Downstream Products

• 114002-86-7 7a-ethyl-3,5-diphenyl-dihydro-oxazolo[3,4-c]oxazole 
• 60204-78-6 2a-ethyl-4a,6a-dimethyl-hexahydro-1,4-dioxa-6b-aza-cyclopenta[cd]pentalene 
• 81419-25-2 2,2'-dithiobisbenzamide> 
• 24498-17-7 2-(1-ethyl-pentyl)-4-ethyl-4-hydroxymethyl-4,5-dihydro-oxazol 
• 24448-07-5 2-undecyl-4-ethyl-4-hydroxymethyl-1,3-oxazoline. 
• 860681-21-6 rac-2-benzamido-2-(hydroxymethyl)butyl benzoate 
• 10581-72-3 N-(1-hydroxy-2-(hydroxymethyl)butan-2-yl)benzamide 
• 1452783-14-0 C₂₈H₂₅N₃O₃ 
• 1452783-15-1 C₂₈H₂₅N₃O₃ 
• 1452783-13-9 C₂₈H₂₅N₃O₃ 
• 2740-66-1 1-(1,1-bis-hydroxymethyl-propyl)-3-phenyl-thiourea 
• 60204-81-1 2a,4a,6a-triethyl-hexahydro-1,4-dioxa-6b-aza-cyclopenta[cd]pentalene 
• 24498-18-8 (4-ethyl-2-phenyl-4,5-dihydro-oxazol-4-yl)-methanol 
• 100887-53-4 2-ethyl-2-(3-cyclohexyl-propylamino)-propane-1,3-diol 

Related news

Molar heat capacities of aqueous 2-Amino-2-ethyl-1,3-propanediol (cas 115-70-8) solutions and their ternary mixtures containing piperazine or lithium salts08/22/2019

The molar heat capacities of a primary sterically hindered amine 2-amino-2-ethyl-1,3-propanediol (AEPD) and its aqueous solutions, in the whole range of concentrations, were measured at temperatures from 303.15 K to 353.15 K by heat flow differential scanning calorimetry. The molar heat capaciti...detailed

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