32899-85-7

Upstream product

• 13206-46-7 2-bromo-2-methylpropanal 
• 78-84-2 isobutyraldehyde 
• 917-93-1 2-chloroisobutyraldehyde 
• 5339-41-3 1-Isopropyl-4,4-dimethyl-2-azabutadien 
• 77144-87-7 N-isobutylidene-2-methylpropenylamine 

Downstream Products

• 13206-50-3 5,5-Dimethyl-2-isopropyl-thiazolidin-nitril-(4) 

Relevant academic research and scientific papers

Biocatalytic Reduction of 2-Monosubstituted 3-Thiazolines Using Imine Reductases

The application of a straightforward biocatalytic technology for the reduction of racemic 2-monosubstituted 3-thiazolines, which are easily prepared via Asinger-multicomponent reaction, is reported. The biocatalytic reduction yields racemic 2-monosubstituted 3-thiazolidines, which are difficult to be prepared by means of classic chemical routes, in moderate to high yields. Moreover, our study clarifies the stereochemical reaction course of the biocatalytic reduction. Furthermore, the efficiency of this biocatalytic technology is demonstrated in an experiment at an elevated substrate concentration of 60?mM leading to 96% conversion.

Method for synthesizing a industry and the process of cysteamine hydrochloride (by machine translation)

The invention relates to a method for synthesizing a industry and the cysteamine hydrochloride process, in order to isobutyl aldehyde as the starting material, after condensation, reduction, open-loop re-ring, ring-opening reaction. The beneficial effects of this invention: through condensation reaction with ammonia in the water instead of the ammonia, and the reduction of the sodium borohydride solution in the following direct input from the liquid level in the reaction system, the reaction efficiency; in the ring-opening reaction have been retained in the arylhydrazines as ring-opening reagent, but will open-loop product in the system without a separate re-ring, the ring will again after the purification of the products undergo rectification, in acidic conditions to obtain a compound of open-loop, greatly reduces the toxic substances phenyl hydrazine residue. (by machine translation)

Practical, efficient synthesis of N-mono-substituted β-amino tertiary thiols via reductive ring-opening of 3-thiazolines

An efficient synthesis of N-mono-substituted β-amino tertiary thiols by reductive ring-opening of 3-thiazolines, obtained by use of the Asinger reaction, is described. This synthesis be regarded as a complementary approach for aminolytic ring-opening of t

Tetrahydrothiazole phosphonic acids or esters thereof

This invention relates to tetrahydrothiazole phosphonic acids or phosphonates and to the preparation thereof by reacting dihydrothiazoles with phosphorous acid or esters thereof.

Process of making penicillamine

Penicillamine and its hydrochloride are made by reacting isobutyraldehyde with elemental sulfur or a sulfur-containing compound and with gaseous ammonia so as to form 2-isopropyl-5.5-dimethyl-thiazoline-Δ3, then reacting the latter compound with substantially anhydrous hydrogen cyanide so as to form the corresponding thiazolidine 4-carbonitrile, thereupon treating the latter compound with an excess of concentrated hydrochloric acid at an elevated temperature and separating the components of the mixture formed and recovering the penicillamine hydrochloride which may then be converted to the free D,L-penicillamine.