329008-82-4Relevant academic research and scientific papers
DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION
-
Page/Page column 32; 33, (2011/07/08)
The present invention relates to compounds of formula (I) below in which: —R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, —R2 and R4 repr
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers
Lawrence, Nicholas J.,Rennison, David,Woo, Meiki,McGown, Alan T.,Hadfield, John A.
, p. 51 - 54 (2007/10/03)
A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest. (C) 2000 Elsevier Science Ltd.
