2644-70-4 Usage
Description
Hydrazine monohydrochloride is a white to slightly beige crystalline compound with orthorhombic crystal structure. It has a density of 1.5 g/cm3, melts at 93°C, and decomposes around 200°C. Hydrazine monohydrochloride is very soluble in water (37 g/100mL at 20°C) and slightly soluble in alcohol.
Uses
Used in Chemical Synthesis:
Hydrazine monohydrochloride is used as a catalyst in the synthesis of titanium oxide polymers via the catalytic sol-gel process. This process allows for the creation of amorphous titanium dioxide (TiO2) thin films with high refractive indices and high transparency, which are useful in various applications such as coatings and optical devices.
Used in Pharmaceutical Industry:
Hydrazine monohydrochloride is used in the preparation of ethyl 3-ethoxy-1H-pyrazole-4-carboxylate, which is an important intermediate in the synthesis of pharmaceutical compounds.
Used in Chemical Derivatives:
Hydrazine hydrochloride is used to prepare other hydrazine derivatives, which can be utilized in various chemical reactions and processes.
Physical and Chemical Properties:
Hydrazine monohydrochloride is characterized by its white flakes and orthorhombic crystals. It has a density of 1.5 g/cm3 and melts at 93°C, while decomposing around 200°C. Hydrazine monohydrochloride is very soluble in water (37 g/100mL at 20°C) and slightly soluble in alcohol, making it suitable for use in various chemical processes and applications.
Preparation
Hydrazine hydrochloride is prepared by the reaction of hydrazine with hydrogen chloride:
N2H4 + HCl → N2H4 ?HCl
Hazard
Hydrazine hydrochloride is moderately toxic by all routes of exposure. Theoral LD50in mice is 126 mg/kg.
Purification Methods
Prepare it by dropwise addition of cold conc HCl to cold liquid hydrazine in equimolar amounts. The crystals are harvested from water and are twice recrystallised from absolute MeOH and dried under a vacuum. [Kovack et al. J Am Chem Soc 107 7360 1985.]
Toxicity evaluation
Hydrazine hydrochloride is moderately toxic by all routes of exposure. The oral LD50 in mice is 126 mg/kg.
Check Digit Verification of cas no
The CAS Registry Mumber 2644-70-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,4 and 4 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2644-70:
(6*2)+(5*6)+(4*4)+(3*4)+(2*7)+(1*0)=84
84 % 10 = 4
So 2644-70-4 is a valid CAS Registry Number.
InChI:InChI=1/ClH.H4N2/c;1-2/h1H;1-2H2/p-1
2644-70-4Relevant articles and documents
Methods of treating cytokine mediated diseases
-
, (2008/06/13)
Disclosed are methods of treating certain cytokine mediated diseases or conditions using novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein.
Process for producing cyclic hydrazine derivatives, tetra-hydropyridazine and hexahydropyridazine
-
, (2008/06/13)
The present invention relates to a process for producing alicyclic hydrazine derivatives, tetrahydropyridazine and hexahydropyridazine which are useful as intermediate starting materials such as medicines and agricultural chemicals. Especially, the present invention provides; a process for producing an alicyclic hydrazine derivative or its hydrohalogenic acid salt, which comprises reacting a hydrazine hydrohalogenic acid salt with a diol compound or an alicyclic ether compound in the presence of an excessive inorganic acid existing in a free form or in the form of an acid addition salt; a process for producing tetrahydropyridazine from 1-aminopyrrolidine, which comprises oxidizing 1-aminopyrrolidine with an oxidizing agent to form tetrahydropyridazine; and a process for producing hexahydropyridazine, which comprises oxidizing 1-aminopyrrolidine with an oxidizing agent, synthesizing tetrahydropyridazine, and thereafter, hydrogenating the tetrahydropyridazine in the presence of a base.
