32937-33-0

Upstream product

• 50983-21-6 1,4-Cyclohexadien-1-carbonsaeure-methylester 
• 4315-35-9 cyclohexa-1,4-diene-1-carboxylic acid 
• 106-99-0 buta-1,3-diene 
• 922-67-8 propynoic acid methyl ester 
• 21802-84-6 (cyclohexa-1,4-dienyl)methylamine 

Downstream Products

• 108-95-2 phenol 
• 3045-32-7 2-(1-hydroxy-1-methylethyl)phenol 
• 90-01-7 salicylic alcohol 
• 90534-57-9 Kohlensaeure-methyl-<1,4-cyclohexadien-1-ylmethyl>-ester 

Relevant academic research and scientific papers

Enantioselective Total Syntheses of Manginoids A and C and Guignardones A and C

An enantioselective synthetic approach for preparing manginoids and guignardones, two types of biogenetically related meroterpenoids, is reported. This bioinspired and divergent synthesis employs an oxidative 1,3-dicarbonyl radical-initiated cyclization and cyclodehydration of the common precursor to forge the central ring of the manginoids and guignardones, respectively, at a late stage. Key synthetic steps include silica-gel-promoted semipinacol rearrangement to form the 6-oxabicyclo[3.2.1]octane skeleton and the Suzuki–Miyaura reaction of vinyl bromide to achieve fragment coupling. This synthesis protocol enables the asymmetric syntheses of four fungal meroterpenoids from commercially available materials.