3045-32-7

Usage

Uses

Used in Chemical Synthesis:
2-(2-hydroxypropan-2-yl)phenol is used as an intermediate in the chemical synthesis process for the preparation of 2,4’-Bisphenol A (B519490), a derivative that is specifically utilized in the production of low-molecular-weight epoxy resins. Its role in this synthesis is crucial, as it serves as a building block for the final product, contributing to the development of materials with specific properties and applications.
Used in Epoxy Resin Industry:
In the epoxy resin industry, 2-(2-hydroxypropan-2-yl)phenol is used as a key component in the production of low-molecular-weight epoxy resins. These resins are known for their excellent adhesion, mechanical properties, and chemical resistance, making them ideal for a wide range of applications, including coatings, adhesives, electrical laminates, and composite materials. The use of 2-(2-hydroxypropan-2-yl)phenol in this industry is driven by its ability to contribute to the development of high-quality epoxy resins with desirable characteristics for various end-use applications.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 60-29-7 diethyl ether 
• 27701-23-1 methyl 2-(methoxymethyloxy)benzoate 
• 119-36-8 methyl salicylate 
• 10277-93-7 2-isopropenylphenol 
• 118-93-4 o-hydroxyacetophenone 
• 917-54-4 methyllithium 
• 77023-21-3 1-(hydroxymethyl)benzene oxide 
• 77023-22-4 1-(2-hydroxy-2-propyl)benzene oxide 
• 95-56-7 2-hydroxybromobenzene 
• 67-64-1 acetone 
• 676-58-4 methylmagnesium chloride 
• 77023-02-0 1-(hydroxymethyl)-1,2-oxido-4-cyclohexene 
• 77023-23-5 (3,4-Dibromo-7-oxa-bicyclo[4.1.0]hept-1-ylmethoxy)-trimethyl-silane 

Downstream Products

• 10277-93-7 2-isopropenylphenol 
• 82466-10-2 2,4,4-Trimethyl-4H-benzo[1,3]dioxine 
• 5026-12-0 2-(2-hydroxyphenyl)-2,4,4-trimethylchroman 
• 63661-69-8 4'-hydroxy-2,4,4-trimethylflavan 
• 1608-68-0 2-isopropyl-phenyl acetate 
• 39477-82-2 2-(2-hydroxyphenyl)-2-methoxypropane 
• 1196734-02-7 C₁₂H₁₈O₃ 
• 1196734-03-8 C₂₀H₂₁NO₄ 
• 870553-71-2 C₁₁H₁₆O₃ 
• 1632131-06-6 3-acetyl-2,4,4-trimethyl-4H-chromene 
• 1429879-02-6 2-[2-(2-azido-2-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}ethoxy)phenyl]propan-2-ol 
• 1452807-42-9 C₂₉H₂₈ClNO₅S 
• 1429879-01-5 2-[2-(2-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-2-hydroxyethoxy)phenyl]propan-2-ol 
• 38865-54-2 <1-(2-Hydroxyphenyl)-1-methylethyl>-(2-isopropenylphenyl)-ether 

Relevant academic research and scientific papers

Regioselective reductive openings of acetals; mechanistic details and synthesis of fluorescently labeled compounds

Regioselective reductive openings of mixed phenolic-benzylic acetals, using BH3·NMe3-AlCl3, was investigated, and a mechanism where the outcome is directed by the electrostatic potential of the two oxygen atoms is presente

Synthesis of acyclic and cyclic phosphonates based on substituted 2-hydroxybenzylic alcohols

A convenient synthesis of benzylic phosphonates and 2,3-dihydrobenzo[d][1,2]oxaphosphole 2-oxides substituted at the aromatic ring, as well as their precursors, 2-hydroxybenzylic alcohols, from the derivatives of salicylic aldehyde, salicylic acid, and 2-hydroxyacetophenone bearing an additional hydroxy or methoxy group at the para position of the aromatic ring was developed. For the first time, the possibility of selective demethylation of the methoxy group positioned ortho to the methylene phosphonate fragment with retention of the methoxy group at the para position was shown.

Multicomponent Condensation Reactions via ortho-Quinone Methides

Iron(III) salts promote the condensation of aldehydes or acetals with electron-rich phenols to generate ortho-quinone methides that undergo Diels - Alder condensations with alkenes. The reaction sequence occurs in a single vessel to afford benzopyrans in up to 95% yield. The reaction was discovered while investigating a two-component strategy using 2-(hydroxy(phenyl)methyl)phenols to access the desired ortho-quinone methide in a Diels - Alder condensation. The two-component condensation also afforded the corresponding benzopyran products in yields up to 97%. Taken together, the two- and three-component strategies using ortho-quinone methide intermediates provide efficient access to benzopyrans in good yields and selectivities.

MODIFIED CYTOSINE POLYNUCLEOTIDE OLIGOMERS AND METHODS

Disclosed are modified cytosine bases that provide enhanced base-pairing affinity for guanine bases in polynucleotide hybridization complexes. Also disclosed are polynucleotide oligomers, polynucleotide hybridization complexes that comprise such modified

CYSTEINYL LEUKOTRIENE ANTAGONISTS

The present invention relates to novel cysteinyl leukotriene (specifically LTD4) antagonists, mainly to quinolin, quinoxaline or benz[c]thiazole derivatives represented by the general formula (I), or the pharmaceutically acceptable salt thereof, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders related to cysteinyl leukotriene, in mammals, more specially in humans.

CYSTEINYL LEUKOTRIENE ANTAGONISTS

The present invention relates to novel cysteinyl leukotriene (specifically LTD4) antagonists, mainly to quinolin, quinoxaline or benz[c]thiazole derivatives represented by the general formula (I), or the pharmaceutically acceptable salt thereof, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders related to cysteinyl leukotriene, in mammals, more specially in humans.

10A-AZALIDE COMPOUND HAVING 4-MEMBERED RING STRUCTURE

A 10a-azalide compound having a 4-membered ring structure crosslinked at the 10a- and 12-positions, which is represented by the formula (I), and is effective on even Haemophilus influenzae, or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).

HETEROCYCLIC COMPOUND

The present invention relates to wherein each symbol is as defined in the specification. The compound of the present invention has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of disease and condition mediated by increased RBP4.

ortho-Effect on the acid-catalyzed hydration of 2-substituted α-methylstyrenes

α-Methylstyrene and nine ortho-substituted analogs have been synthesized and the kinetics of their acid-catalyzed hydration in aqueous solutions of sulfuric acid at 25°C have been investigated. The kinetic acidity function HS has been constructed from the dependence of the observed rate constants kobs on the sulfuric acid concentration. The catalytic rate constants of the acid-catalyzed hydration kortho have been calculated as well. The identical shape of the kinetic acidity functions for ortho- and para-derivatives confirms what the consistent mechanism A-SE2 of the acid-catalyzed hydration has already proved for the corresponding paraderivatives. The A-SE2 mechanism involves a rate-determining proton transfer of the hydrated proton to the substrate. From the dependence of the catalytic rate constants of the ortho-derivatives on the catalytic rate constants of the para-derivatives, it is seen that the logarithm of the catalytic rate constant for hydrogen as a substituent is markedly out of the range of the other substituents and, simultaneously, that the ortho-derivatives react significantly slower than the corresponding para-derivatives. In correlation with the substitent constants σp+, a reaction constant of ρ+= -1.45 have been found. The constant is, in absolute value, considerably smaller than that for para-derivatives (ρ+ = -3.07). In parallel, the steric effects are enforced more significantly for the monoatomic substituents (slope of the Charton's constants 3.92) than for substituents including more atoms (slope of the Charton's constants 2.09). A small value of the reaction constant ρ+ has been elucidated due to the lower conjugation between the reaction centre and the benzene ring as a consequence of the geometric twist of the reaction centre out of the main aromatic plane accompanied by fading mesomeric interaction between the reaction centre and the substituents attached to the benzene ring. The isopropyl group in the carbocation is twisted less out of the aromatic plane for the monoatomic substituents and, therefore, also a small difference in the bulk of substituents has considerable steric influence on the conjugation between the carbocation and the benzene ring bearing substituents. On the contrary, the isopropyl group in the carbocations with polyatomic substituents is twisted to such a degree that changes in the bulk of substituents affect the resonant stabilization negligibly. Similar conclusions were also deduced from the correlations of the substitution constants σI and σR+.

Facile construction of functionalized 4H-chromene via tandem benzylation and cyclization

A series of functionalized 4H-chromenes have been constructed by using a novel FeCl3-catalyzed benzylation-cyclization tandem reaction. The Royal Society of Chemistry.