3298-49-5

Basic information

• Product Name: 2-Formyl-1,1-dimethylhydrazine
• Synonyms: 2-Formyl-1,1-dimethylhydrazine;N',N'-diMethylforMohydrazide;ForMic acid, 2,2-diMethylhydrazide;N,N-DiMethylforMhydrazide
• CAS NO: 3298-49-5
• Molecular Formula: C₃H₈N₂O
• Molecular Weight: 88.1092
• Mol File: 3298-49-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 57.8 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 72-75 °C(Press: 2.3 Torr)
• Appearance: /
• Density: 0.963±0.06 g/cm3(Predicted)
• PKA: 13.59±0.46(Predicted)
• CAS DataBase Reference: 2-Formyl-1,1-dimethylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Formyl-1,1-dimethylhydrazine(3298-49-5)
• EPA Substance Registry System: 2-Formyl-1,1-dimethylhydrazine(3298-49-5)

Safety Data

• Hazardous Substances Data: 3298-49-5(Hazardous Substances Data)

Usage

General Description

2-Formyl-1,1-dimethylhydrazine, also known as dimethylformylhydrazine (DMFH), is a chemical compound with the formula CH3N (CH3)NCHO. It is a hydrazine derivative and is recognized for its use as a liquid rocket propellant in combination with nitrogen tetroxide or nitric acid. This organic compound is a versatile reagent in organic synthesis, and it is usually present as a colorless or yellowish liquid with a strong, unpleasant odor. It is highly flammable, and its exposure can cause severe health impacts, including severe burns and eye damage.

Upstream product

• 64-18-6 formic acid 
• 4702-38-9 diazomethane 
• 74-88-4 methyl iodide 
• 57-14-7 N,N-Dimethylhydrazine 
• 109-94-4 formic acid ethyl ester 
• 107-31-3 Methyl formate 

Downstream Products

• 1741-01-1 Trimethylhydrazin 
• 87132-48-7 1-benzyl-2-formyl-1,1-dimethylhydrazinium bromide 
• 87132-46-5 1-cinnamyl-2-formyl-1,1-dimethylhydrazinium bromide 

Relevant articles and documents

Catalyst for the degradation of 1,1-dimethylhydrazine and its by-product N-nitrosodimethylamine in propellant wastewater

A three-component metal catalyst was prepared and used in the process of catalytic wet peroxide oxidation (CWPO) for the degradation of unsymmetrical dimethylhydrazine (UDMH) in propellant wastewater with H2O2. It was structurally characterized using scanning electron spectroscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and energy-dispersive X-ray spectroscopy (EDX), and its catalytic activity was evaluated using indexes such as the efficiency of UDMH degradation and chemical oxygen demand (COD) removal and the concentrations of ammonia (NH3-N), formaldehyde (HCHO), total nitrogen (TN), total organic carbon (TOC) and N-nitrosodimethylamine (NDMA). Besides, the reaction system was monitored using UV-Vis full wavelength scanning spectroscopy and liquid chromatography-mass spectroscopy (LC-MS). As a result, it was observed that the degradation mechanism involved OH attacking the amino group and homocoupling in UDMH with the simultaneous transformation of the active component CuII/I. Based on investigation of the reaction factors (H2O2 dosage, temperature, catalyst dosage, pH and initial concentration of UDMH) focusing on the removal of NDMA, the optimal conditions for CWPO with a three-component metal catalyst were determined. The high treatable concentration of UDMH (500 mg L-1), rapid rate and good reusability with a high efficiency of UDMH degradation and COD removal (99.9% in 10 min and 94.6% in 30 min, respectively) and the low concentration of NDMA are merits of the present catalyst.

N-Ammonium Ylide Mediators for Electrochemical C-H Oxidation

The site-specific oxidation of strong C(sp3)-H bonds is of uncontested utility in organic synthesis. From simplifying access to metabolites and late-stage diversification of lead compounds to truncating retrosynthetic plans, there is a growing need for new reagents and methods for achieving such a transformation in both academic and industrial circles. One main drawback of current chemical reagents is the lack of diversity with regard to structure and reactivity that prevents a combinatorial approach for rapid screening to be employed. In that regard, directed evolution still holds the greatest promise for achieving complex C-H oxidations in a variety of complex settings. Herein we present a rationally designed platform that provides a step toward this challenge using N-ammonium ylides as electrochemically driven oxidants for site-specific, chemoselective C(sp3)-H oxidation. By taking a first-principles approach guided by computation, these new mediators were identified and rapidly expanded into a library using ubiquitous building blocks and trivial synthesis techniques. The ylide-based approach to C-H oxidation exhibits tunable selectivity that is often exclusive to this class of oxidants and can be applied to real-world problems in the agricultural and pharmaceutical sectors.

Sulfonic acid supported on hydroxyapatite-encapsulated-γ-Fe2O3 nanocrystallites as a magnetically Br?nsted acid for N-formylation of amines

Treatment of aqueous formic acid (85%) with structurally diverse amines in the presence of a catalytic amount of sulfonic acid supported on hydroxyapatite-encapsulated-γ-Fe2O3 [HAp@-γ-Fe2O3] (0.9 mol.%) as a heterogeneous, reusable and highly efficient catalyst gave the corresponding formamides in good to excellent yields at room temperature. The magnetically catalytic system was recovered by-passing time consuming filtration operation by using an external magnet device. In addition to facility, this methodology, it also enhances product purity and promises economic as well as environmental benefits.