329911-78-6Relevant articles and documents
Synthesis and properties of peptidomimetics - Inhibitors of platelet aggregation
Andronati,Krysko,Kabanov,Karaseva,Kabanova
, p. 15 - 21 (2007/10/03)
The literature data on effective approaches to the development of the novel peptidomimetics, antagonists of fibrinogen GP IIb/IIIa receptors as potential antithrombotic agents are generalized and systematized in the review. The data obtained by the authors on the synthesis and properties of novel peptidomimetics are reported.
Synthesis and antiaggregation activity of a new RGDF peptidomimetic
Krys'ko,Kabanov,Polishchuk,Chugunov,Pavlovskii,Andronati,Mazepa,Kabanova,Karaseva
, p. 948 - 952 (2007/10/03)
A new RGDF peptidomimetic, [4-oxo-4-(pyperazin-1-yl)butyryl]glycyl-D,L-β-phenyl-β-alanine was synthesized. The arginyl mimetic used was the 4-oxo-4-(piperazin-1-yl)butanoic acid residue, and the Asp-Phe chain is replaced by a β-phenyl-β-alanine residue. The synthesized pseudopeptide showed ability to inhibite ADF-induced thrombocyte aggregation in a thrombocyte-rich rat blood plasma (IC50 8.7 × 10-9 M).