329940-36-5

Basic information

• Product Name: N-methyl-3-nitro-4-methylbenzamide
• Synonyms: N-methyl-3-nitro-4-methylbenzamide
• CAS NO: 329940-36-5
• Molecular Weight: 194.19
• Mol File: 329940-36-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-methyl-3-nitro-4-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-3-nitro-4-methylbenzamide(329940-36-5)
• EPA Substance Registry System: N-methyl-3-nitro-4-methylbenzamide(329940-36-5)

Safety Data

• Hazardous Substances Data: 329940-36-5(Hazardous Substances Data)

Upstream product

• 18370-11-1 N-methyl-p-methylbenzamide 
• 7697-37-2 nitric acid 
• 74-89-5 methylamine 
• 10397-30-5 4-methyl-3-nitrobenzoyl chloride 
• 99-94-5 p-Toluic acid 
• 104-85-8 para-methylbenzonitrile 
• 874-60-2 4-methyl-benzoyl chloride 
• 106-49-0 p-toluidine 

Downstream Products

• 54884-19-4 3-amino-4-methylbenzoic acid methylamide 
• 1383110-96-0 C₂₂H₂₅N₅O₂ 

Relevant articles and documents

The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4- oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases

A novel, potent and selective quinazolinone series of inhibitors of p38α MAP kinase has been identified. Modifications designed to address the issues of poor aqueous solubility and high plasma protein binding as well as embedded aniline functionalities resulted in the identification of a clinical candidate N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin- 3(4H)-yl]benzamide (AZD6703). Optimisation was guided by understanding of the binding modes from X-ray crystallographic studies which showed a switch from DFG 'out' to DFG 'in' as the inhibitor size was reduced to improve overall properties.