54884-19-4

Basic information

• Product Name: 3-AMINO-N,4-DIMETHYLBENZAMIDE
• Synonyms: 3-AMINO-N,4-DIMETHYLBENZAMIDE;AKOS BBV-009596;OTAVA-BB 1134989;3-amino-N,4-dimethylbenzamide(SALTDATA: FREE)
• CAS NO: 54884-19-4
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.2
• Mol File: 54884-19-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 325.038°C at 760 mmHg
• Flash Point: 150.378°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.574
• PKA: 15.31±0.46(Predicted)
• CAS DataBase Reference: 3-AMINO-N,4-DIMETHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-N,4-DIMETHYLBENZAMIDE(54884-19-4)
• EPA Substance Registry System: 3-AMINO-N,4-DIMETHYLBENZAMIDE(54884-19-4)

Safety Data

• Statements: 36
• Safety Statements: 26
• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 54884-19-4(Hazardous Substances Data)

Usage

General Description

3-AMINO-N,4-DIMETHYLBENZAMIDE is a chemical compound with the molecular formula C9H12N2O. It appears as a white to light yellow crystalline powder and is primarily used as an intermediate in the synthesis of pharmaceuticals and organic compounds. It is known for its ability to act as a pharmaceutical intermediate and is commonly used in the manufacturing of drugs and other organic compounds. Additionally, 3-AMINO-N,4-DIMETHYLBENZAMIDE has been studied for its potential therapeutic properties and is of interest to researchers in the pharmaceutical industry.

InChI:InChI=1/C9H12N2O/c1-6-3-4-7(5-8(6)10)9(12)11-2/h3-5H,10H2,1-2H3,(H,11,12)

Upstream product

• 10397-30-5 4-methyl-3-nitrobenzoyl chloride 
• 96-98-0 4-methyl-3-nitrobenzoic acid 
• 329940-36-5 N-methyl-3-nitro-4-methylbenzamide 
• 2458-12-0 3-amino-p-toluic acid 
• 2592-95-2 benzotriazol-1-ol 

Downstream Products

• 1005196-64-4 methyl 5-methyl-4-(2-methyl-5-(methylcarbamoyl)phenylamino)pyrrolo[1,2-f][1,2,4]triazine-6-carboxylate 
• 1026765-63-8 C₂₀H₂₃N₅O₃ 
• 482344-81-0 3-(5-bromo-2-chloro-pyrimidin-4-ylamino)-4,N-dimethyl-benzamide 
• 1023296-93-6 C₁₆H₁₈BrN₃O₃S 
• 630107-80-1 Compound 4A 
• 482344-60-5 3-(6-chloro-pyrimidin-4-ylamino)-4,N-dimethyl-benzamide 
• 745078-00-6 5-amino-2-bromo-N,4-dimethylbenzamide 

Relevant articles and documents

The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4- oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases

A novel, potent and selective quinazolinone series of inhibitors of p38α MAP kinase has been identified. Modifications designed to address the issues of poor aqueous solubility and high plasma protein binding as well as embedded aniline functionalities resulted in the identification of a clinical candidate N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin- 3(4H)-yl]benzamide (AZD6703). Optimisation was guided by understanding of the binding modes from X-ray crystallographic studies which showed a switch from DFG 'out' to DFG 'in' as the inhibitor size was reduced to improve overall properties.

PYRAZOLO-PYRIMIDINE ANILINE COMPOUNDS

Compounds having the formula (I), where all substituents are as defined herein, and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors.