330156-50-8

Basic information

• Product Name: (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
• Synonyms: benzeneMethanol, 2,6-dichloro-3-fluoro-α-Methyl-, (alphaR)-;BenzeneMethanol,2,6-dichloro-3-fluoro-a-Methyl-, (aR)-;(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol;Crizotinib InterMediate;Benzenemethanol, 2,6-dichloro-3-fluoro-α-methyl-, (αR)-;(R)-2,6-Dichloro-3-fluoro-alpha-methylbenzyl Alcohol;(R)-2,6-Dichloro-3-fluoro-α(R)-2,6-Dichloro-3-fluoro-α-methylbenzyl Alcohol
• CAS NO: 330156-50-8
• Molecular Formula: C₈H₇Cl₂FO
• Molecular Weight: 209.04
• EINECS: 1312995-182-4
• Product Categories: Chiral Compounds
• Mol File: 330156-50-8.mol
• Article Data: 23

Chemical Properties

• Melting Point: 41.0 to 45.0 °C
• Boiling Point: 261 °C
• Flash Point: 112 °C
• Appearance: /
• Density: 1.406
• Vapor Pressure: 0.00589mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 13.30±0.20(Predicted)
• CAS DataBase Reference: (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol(330156-50-8)
• EPA Substance Registry System: (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol(330156-50-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 330156-50-8(Hazardous Substances Data)

Usage

Description

(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an alcohol derivative and can be used as a pharmaceutical intermediate.

Uses

(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is used in the synthesis of anti-tumor molecular targeted drug of Crizotinib (C785000).

InChI:InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/m1/s1

Upstream product

• 290835-85-7 2',6'-dichloro-3'-fluoroacetophenone 
• 756520-66-8 1-(2,6-dichloro-3-fluorophenyl)ethanol 
• 877397-67-6 1-(2,6-dichloro-3-fluorophenyl)ethyl acetate 

Downstream Products

• 1370651-29-8 C₁₂H₉Cl₃FN₃O 
• 1201916-93-9 C₃₀H₃₄Cl₂FN₅O₇ 
• 1201916-63-3 {6-amino-5-[(2,6-dichloro-3-fluorophenyl)ethoxy]-pyridazin-3-yl}-N-(1-ethyl-6-oxo-1,6-dihydro-pyridin-3-yl)carboxamide 
• 1370651-32-3 C₂₂H₂₅Cl₃FN₃O₅ 
• 1370651-34-5 C₂₅H₃₀Cl₂FN₃O₇ 
• 1370651-36-7 6-[bis(tert-butoxycarbonyl)amino]-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridazine-3-carboxylic acid 
• 1370652-58-6 C₂₉H₃₂Cl₂FN₅O₇ 
• 1370652-56-4 {5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-aminopyridazin-3-yl}-N-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)carboxamide 
• 1365267-27-1 6-amino-5-[(1{R})-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-{N}-[4-[(3{R},5{S})-3,5-dimethylpiperazine-1-carbonyl]phenyl]pyridazine-3-carboxamide 
• 1370651-39-0 C₃₅H₄₁Cl₂FN₆O₇ 
• 1370651-40-3 C₃₅H₃₄Cl₂FN₅O₇ 
• 1370651-02-7 {5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-aminopyridazin-3-yl}-N-[4-(4-pyridylcarbonyl)phenyl]carboxamide 
• 877397-65-4 (S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol 
• 877397-68-7 (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate 

Relevant articles and documents

Biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3- fluorophenyl)ethanol in enantiomerically pure form

An efficient four-step biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol in enantiomerically pure form is described. This compound is a key intermediate required for the preparation of PF-2341066, a potent inhibitor of c-

Manganese-Catalyzed Enantioselective Hydrogenation of Simple Ketones Using an Imidazole-Based Chiral PNN Tridentate Ligand

A series of Mn(I) catalysts containing imidazole-based chiral PNN tridentate ligands with controllable 'side arm' groups have been established, enabling the inexpensive base-promoted asymmetric hydrogenation of simple ketones with outstanding activities (up to 8200 TON) and good enantioselectivities (up to 88.5percent ee). This protocol features wide substrate scope and functional group tolerance, thereby providing easy access to a key intermediate of crizotinib.

Chiral ferrocene phosphine-nitrogen-nitrogen tridentate ligand as well as preparation method and application thereof

The invention discloses a chiral ferrocene phosphine-nitrogen-nitrogen tridentate ligand as well as a preparation method and an application thereof. The general structural formula of the chiral ferrocene phosphine-nitrogen-nitrogen tridentate ligand is shown in formula (I) or formula (II), wherein R1 and R2 are independently selected from C1-C6 alkyl, C3-C6 cycloalkyl, aryl or heterocyclic aryl respectively; R3 is aryl, heterocyclic aryl or C1-C6 alkyl, and R4 is hydrogen, C1-C6 alkyl, aryl or heterocyclic aryl; the general structural formula in the formula (I) and the formula (II) contains animidazole group or a substituted benzimidazole group respectively; one or more substituent groups exist on a benzene ring of the substituted benzimidazole group, and each substituent group is independently selected from H or C1-C4 alkyl. The chiral ferrocene phosphine-nitrogen-nitrogen tridentate ligand has the advantages that the tridentate ligand is convenient to synthesize, exists in the air stably and can be coordinated with cheap metal to prepare a cheap metal catalyst, and the cheap metal catalyst is well applied to asymmetric hydrogenation reactions of ketone.