33033-84-0

Basic information

• Product Name: 6,7-DIMETHOXY-1-(3,4,5-TRIMETHOXY-PHENYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• Synonyms: 6,7-DIMETHOXY-1-(3,4,5-TRIMETHOXY-PHENYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• CAS NO: 33033-84-0
• Molecular Formula: C₂₀H₂₅NO₅
• Molecular Weight: 359.42
• Mol File: 33033-84-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 111-112 °C
• Boiling Point: 475.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.135±0.06 g/cm3(Predicted)
• PKA: 7.91±0.40(Predicted)
• CAS DataBase Reference: 6,7-DIMETHOXY-1-(3,4,5-TRIMETHOXY-PHENYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DIMETHOXY-1-(3,4,5-TRIMETHOXY-PHENYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(33033-84-0)
• EPA Substance Registry System: 6,7-DIMETHOXY-1-(3,4,5-TRIMETHOXY-PHENYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(33033-84-0)

Safety Data

• Hazardous Substances Data: 33033-84-0(Hazardous Substances Data)

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 63375-81-5 2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 121998-73-0 4,4-dimethyl-2-(3,4,5-trimethoxyphenyl)oxazolidine 
• 128741-54-8 [2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-[1-(3,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-amine 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 3161-21-5 1-(3,4,5-trimethoxylphenyl)-3,4-dihydro-6,7-dimethoxyisoquinoline 
• 24456-60-8 6,7-dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline 
• 24456-59-5 6,7-dimethoxy-3,4-dihydroisoquinoline-1(2H)-thione 

Downstream Products

• 3161-13-5 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)isoquinoline 
• 3161-21-5 1-(3,4,5-trimethoxylphenyl)-3,4-dihydro-6,7-dimethoxyisoquinoline 
• 22324-83-0 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Substituted tetrahydroisoquinolines: synthesis, characterization, antitumor activity and other biological properties

This work deals with the molecular design, synthesis and biological activity of a series of tetrahydro[1,4]dioxanisoquinolines and dimethoxyisoquinoline analogues. This study describes the synthesis strategy of these potential antitumor compounds, their multi-step synthesis and their optimization. A series of tetrahydroisoquinolines was synthesized and their cytotoxicity evaluated. Some of these tetrahydroisoquinolines showed promising KRas inhibition, antiangiogenesis activity and antiosteoporosis properties. Molecular modeling studies showed that compound 12 bind in the p1 pocket of the KRas protein making interactions with the hydrophobic residues Leu56, Tyr64, Tyr71 and Thr74 and hydrogen bonds with residues Glu37 and Asp38.

Synthesis and pharmacological properties of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives

Some selected 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized and evaluated as the β-adrenoceptor agents. Some of the compounds showed a weak agonistic or antagonistic activity on these receptors.

Carbon-transfer Reactions with Heterocycles. Part 3. Synthetic Equivalence of Oxazolidines with Carbonyl Compounds

Oxazolidines perform acid catalysed transfer of their C(2) units at the carbonyl group oxidation level to various nucleophiles, resulting in the synthesis of various heterocycles including some β-carboline and isoquinoline alkaloids.