22324-83-0

Usage

Uses

Used in Pharmaceutical Industry:
(+/-)-Cryptostyline III is used as a potential drug candidate for its anti-inflammatory properties, offering a new avenue for the treatment of inflammation-related diseases.
(+/-)-Cryptostyline III is also used as an anti-cancer agent, showing promise in the development of new drugs for the treatment of various types of cancer due to its ability to target and inhibit cancer cell growth.
Used in Neurodegenerative Disorder Treatment:
(+/-)-Cryptostyline III is used as a therapeutic agent for neurodegenerative disorders, leveraging its inhibitory effects on casein kinase 1, an enzyme involved in cellular regulation processes. This application could lead to advancements in managing conditions such as Alzheimer's and Parkinson's diseases.
(+/-)-Cryptostyline III's unique structure and promising biological activities have attracted significant interest from the scientific community, and ongoing research aims to further explore its potential therapeutic applications.

Upstream product

• 16620-96-5 2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 133095-91-7 3,4,5-trimethoxyphenylmagnesium bromide 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 24456-60-8 6,7-dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline 
• 2675-80-1 1,2,3-trimethoxy-5-chlorobenzene 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 128741-54-8 [2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-[1-(3,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-amine 
• 63375-81-5 2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine 
• 82791-57-9 6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxy-phenyl)-2H-isoquinolin-3-one 
• 50-00-0 formaldehyd 
• 82801-28-3 6,7-dimethoxy-2-methyl-3-oxo-1-(3,4,5-trimethoxy)-1,2,3,4-tetrahydroisoquinolone 
• 33033-84-0 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

A one-pot synthesis of (±) cryptostylines I, II, III

A one-pot synthesis of cryptostylines I, II, III, via the Pictet-Spengler reaction is reported.

Total synthesis of racemic 1-aryl-tetrahydroisoquinoline alkaloids

A new synthetic route was developed for the preparation of natural products cryptostyline I, II, III and 1-phenyl-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline. The Liebeskind-Srogl palladium-catalyzed carbon-carbon cross-coupling protocol was use

Transition-Metal-Free Arylation of N -Alkyl-tetrahydroisoquinolines under Oxidative Conditions: A Convenient Synthesis of C1-Arylated Tetrahydro-isoquinoline Alkaloids

A simple protocol for the C1 arylation of tetrahydroisoquinolines with aryl Grignard reagents via diethyl azodicarboxylate (DEAD) mediated oxidative C-H activation under metal-free conditions has been developed. The target compounds, including some natura

Nucleophilic addition of Lewis acid complexed α-amino carbanions to arynes: Synthesis of 1-aryl- N -methyl-1,2,3,4-tetrahydroisoquinolines

The direct C-1 arylation of N-methyl-1,2,3,4-tetrahydroisoquinolines via coupling of α-amino carbanions derived from Lewis acid complexed tetrahydroisoquinolines and in situ generated arynes is described. This process provides an easy access to the title compounds and a new synthetic route to (±)-cryptostyline alkaloids. Georg Thieme Verlag Stuttgart New York.

Synthesis of Racemic Cryptostylines I, II, and III by Radical Cyclization

Three 1-phenyl-1,2,3,4-tetrahydroisoquinoline alkaloids, cryptostylines I, II, and III, have been synthesized in racemic forms via an aryl radical-initiated cyclization.