22324-83-0

Basic information

• Product Name: (+/-)-Cryptostyline III
• Synonyms: (+/-)-Cryptostyline III;1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)isoquinoline;Intermediate of Gantacurium Chloride;(+/-)-cryptostyline
• CAS NO: 22324-83-0
• Molecular Formula: C₂₁H₂₇NO₅
• Molecular Weight: 373.44
• Mol File: 22324-83-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 140-141 °C
• Boiling Point: 462.5 °C at 760 mmHg
• Flash Point: 128 °C
• Appearance: /
• Density: 1.126
• CAS DataBase Reference: (+/-)-Cryptostyline III(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-Cryptostyline III(22324-83-0)
• EPA Substance Registry System: (+/-)-Cryptostyline III(22324-83-0)

Safety Data

• Hazardous Substances Data: 22324-83-0(Hazardous Substances Data)

Usage

General Description

(+/-)-Cryptostyline III is a natural product isolated from the marine sponge (Cryptotethia crypta) that has been investigated for its potential pharmaceutical and medicinal properties. It is a member of the alkaloid family and has a complex chemical structure with a unique pentacyclic ring system. Research has shown that (+/-)-Cryptostyline III has anti-inflammatory and anti-cancer activities, making it a potential candidate for the development of new drugs for the treatment of various diseases. It has also been found to have inhibitory effects on the enzyme casein kinase 1, which plays a role in regulating cellular processes and has implications for the treatment of neurodegenerative disorders. The compound has attracted interest from the scientific community due to its unique structure and promising biological activities, and further research is being conducted to explore its potential therapeutic applications.

Upstream product

• 50-00-0 formaldehyd 
• 33033-84-0 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 82801-28-3 6,7-dimethoxy-2-methyl-3-oxo-1-(3,4,5-trimethoxy)-1,2,3,4-tetrahydroisoquinolone 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 82791-57-9 6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxy-phenyl)-2H-isoquinolin-3-one 
• 63375-81-5 2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine 
• 128741-54-8 [2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-[1-(3,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-amine 
• 16620-96-5 2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 2675-80-1 1,2,3-trimethoxy-5-chlorobenzene 
• 24456-60-8 6,7-dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 133095-91-7 3,4,5-trimethoxyphenylmagnesium bromide 

Relevant articles and documents

A one-pot synthesis of (±) cryptostylines I, II, III

A one-pot synthesis of cryptostylines I, II, III, via the Pictet-Spengler reaction is reported.

Transition-Metal-Free Arylation of N -Alkyl-tetrahydroisoquinolines under Oxidative Conditions: A Convenient Synthesis of C1-Arylated Tetrahydro-isoquinoline Alkaloids

A simple protocol for the C1 arylation of tetrahydroisoquinolines with aryl Grignard reagents via diethyl azodicarboxylate (DEAD) mediated oxidative C-H activation under metal-free conditions has been developed. The target compounds, including some natura

Synthesis of Racemic Cryptostylines I, II, and III by Radical Cyclization

Three 1-phenyl-1,2,3,4-tetrahydroisoquinoline alkaloids, cryptostylines I, II, and III, have been synthesized in racemic forms via an aryl radical-initiated cyclization.