3304-23-2

Basic information

• Product Name: Cyclohexanone, 2-(1-hydroxy-1-methylethyl)-
• Synonyms: Cyclohexanone, 2-(1-hydroxy-1-methylethyl)-
• CAS NO: 3304-23-2
• Molecular Formula: C₉H₁₆O₂
• Molecular Weight: 156.22
• Mol File: 3304-23-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 68-71 °C(Press: 1 Torr)
• Appearance: /
• Density: 1.040±0.06 g/cm3(Predicted)
• PKA: 14.52±0.29(Predicted)
• CAS DataBase Reference: Cyclohexanone, 2-(1-hydroxy-1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 2-(1-hydroxy-1-methylethyl)-(3304-23-2)
• EPA Substance Registry System: Cyclohexanone, 2-(1-hydroxy-1-methylethyl)-(3304-23-2)

Safety Data

• Hazardous Substances Data: 3304-23-2(Hazardous Substances Data)

Usage

General Description

Cyclohexanone, 2-(1-hydroxy-1-methylethyl)-, also known as diisobutylketone, is a chemical compound with the molecular formula C10H20O. It is a colorless liquid with a mild odor that is commonly used as a solvent in various industrial applications, such as coatings, adhesives, and cleaning products. It is produced through the oxidation of diisobutylene and is known to be a skin and eye irritant, and may also cause respiratory irritation. However, it is not considered to be a major environmental concern and has a relatively low potential for bioaccumulation.

Upstream product

• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 67-64-1 acetone 
• 108-94-1 cyclohexanone 
• 71444-26-3 N-cyclohexyl-N-1-cyclohexenylamino-dichloroborane 
• 35365-19-6 2-iodocyclohexanone 
• 874-23-7 2-acetylcyclohexanone 
• 676-58-4 methylmagnesium chloride 
• 1056477-06-5 2-bromocyclohexanone 
• 140112-10-3 C₁₈H₃₁BO 

Downstream Products

• 1569301-18-3 (E)-2-(2-(2,2-dimethylhydrazono)cyclohexyl)propan-2-ol 
• 86186-41-6 1,4,4-trimethyl-2-(trimethylsilyl)spiro<4.5>dec-1-en-6-one 
• 24337-53-9 trans-2-(1-hydroxy-1-methylethyl)cyclohexanol 
• 24337-53-9 cis-2-(1-hydroxy-1-methylethyl)cyclohexanol 
• 13747-73-4 2-isopropylidenecyclohexan-1-one 

Relevant articles and documents

A catalytic, mild and efficient protocol for the C-3 aerial hydroxylation of oxindoles

A mild, high yielding approach to C-3 hydroxylated oxindoles using catalytic quantities of tetrabutylammonium fluoride and air as the stoicheiometric oxidant is reported over a wide range of substitution patterns.

An efficient procedure for the preparation of (E)-α-alkylidenecycloalkanones mediated by a CeCl3·7H2O-NaI system. Novel methodology for the synthesis of (S)-(-)-pulegone

2-Alkylidenecycloalkanones are powerful synthons used as the key intermediates in many important syntheses. Because of their potential, a general method of preparation from readily available starting materials, under very mild conditions, was considered to be worthwhile. Cerium(III) chloride heptahydrate in combination with sodium iodide in refluxing acetonitrile promotes a regio- and stereoselective β-elimination reaction to (E)-2-alkylidenecycloalkanones in 2-(1-hydroxyalkyl)cycloalkanones. The synthetic value of the present procedure is demonstrated by the synthesis of monoterpene (S)-(-)-pulegone (8) in its optically active form.

FACILE ROUTES TO BORON ENOLATES. Et3B-MEDIATED REFORMATSKY TYPE REACTION AND THREE COMPONENTS COUPLING REACTION OF ALKYL IODIDES, METHYL VINYL KETONE, AND CARBONYL COMPOUNDS

Reaction of α-bromoketones with Ph3SnH in the presence of Et3B provides boron enolates which react with carbonyl compounds to give β-hydroxyketones in good yields.Et3B-induced Reformatsky type reaction of α-iodoketones with an aldehyde or ketone proceeds without Ph3SnH.