3304-61-8Relevant articles and documents
Segal
, p. 349,350 (1972)
Preparation of N-acetyl, tert-butyl amide derivatives of the 20 natural amino acids
Ekkati,Campanali,Abouelatta,Shamoun,Kalapugama,Kelley,Kodanko, Jeremy J.
scheme or table, p. 747 - 751 (2010/08/05)
N-Acetyl-AA(amino acid)-NHtBu derivatives of all 20 naturally occurring amino acids have been synthesized. Syntheses were performed via solution-phase methodology with yields that allow for access to gram quantities of substrates, in most cases. Syntheses include the coupling of a hindered amine, tert-butylamine, with each amino acid, either directly or in two steps using an activated ester isolated as an intermediate. The introduction of protecting groups was necessary in some cases. The development of synthetic sequences to access challenging substrates, such as the one derived from asparagine, are discussed.
Acylaminoacetyl Derivatives of Active Methylene Compounds. 2. The Cyclization of the Acetylaminoacetyl Derivatives to α-Substituted Tetramic Acids and the Formation of N-Acetyl-α-substituted Tetramic Acids
Igglessi-Markopoulou, Olga,Sandris, Constantine
, p. 1599 - 1606 (2007/10/02)
The reaction of aceturic acid p-nitrophenyl ester with active methylene compounds Y-CH2-CO2R has been found to give either the normally expected C-acylation compounds 2 (Y = -CN, -CO2R, -COCH3) or N-acetyl-α-Y-substituted tetramic acids 3 (Y = -CO2R, -COC
