33064-23-2

Usage

Molecular weight

258.71 g/mol

Classification

Pyrazole derivative

Functional groups

4-chlorophenyl group, phenyl group

Potential applications

Medicinal chemistry, neuroprotective agents, anti-inflammatory drugs

InChI:InChI=1/C15H11ClN2/c16-13-8-6-12(7-9-13)15-10-11-17-18(15)14-4-2-1-3-5-14/h1-11H

Upstream product

• 91869-72-6 1-[1-(4-Chloro-phenyl)-3-(phenyl-hydrazono)-prop-(E)-ylideneamino]-4,6-diphenyl-1H-pyridin-2-one 
• 31301-39-0 3-(4-chlorophenyl)-isoxazole 
• 100-63-0 phenylhydrazine 
• 2286-35-3 ethyl 3-(4-chlorophenyl)-2-cyanoacrylate 
• 91869-63-5 1-[(E)-1-(4-Chloro-phenyl)-3-dimethylamino-prop-2-en-(E)-ylideneamino]-4,6-diphenyl-1H-pyridin-2-one 
• 99-91-2 para-chloroacetophenone 
• 22959-34-8 1-(4-chlorophenyl)-2-propyn-1-one 
• 91869-66-8 N-(α-methyl-4-chlorobenzylidenamino)-4,6-diphenyl-2-pyridone 

Relevant academic research and scientific papers

Ultrasound assisted synthesis of 1,5-disubstituted pyrazole using Cu(I) catalyst

A new efficient and convenient approach towards the synthesis of pyrazole is described. The α,β-unsaturated cyanoesters were obtained from substituted benzaldehyde and ethyl cyanoacetate by reported methods. 1,5-Disubstituted pyrazoles were synthesized fr

Molybdenum-Mediated One-Pot Synthesis of Pyrazoles from Isoxazoles

A one-pot approach for the direct synthesis of substituted pyrazoles from isoxazoles is reported. The process involves isoxazole N-O bond cleavage mediated by a molybdenum complex, in situ hydrolysis of the resulting β-amino enone to the corresponding 1,3-diketone, followed by pyrazole formation in the presence of hydrazine or substituted hydrazine. Good to excellent yields and regioselectivities are obtained with nonsymmetric isoxazoles. By using readily available starting materials, a wide range of substituted pyrazoles may be synthesized by this method.

Regioselective microwave-assisted synthesis of substituted pyrazoles from ethynyl ketones

Reaction of α,β-ethynyl ketones and hydrazine derivatives gives 1,3- and 1,5-disubstituted pyrazoles in good yield. Microwave irradiation in concentrated hydrochloric acid-methanol (1.5% v/v), with concurrent cooling at sub-ambient temperatures or at 120°

New Synthesis of Pyrazole and Isoxazole Derivatives

A convenient synthesis of 5-aryl-1-phenylpyrazoles and 5-arylisoxazoles, from readily available ketimine 1 dimethylformamide dimethylacetal and phenylhydrazine or hydroxylamine, is described.