33065-61-1

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indene, 6-bromois used as a building block for the production of various pharmaceuticals. Its unique structure allows for the synthesis of complex organic compounds with potential therapeutic applications.
Used in Agrochemical Industry:
1H-Indene, 6-bromois also used in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties make it suitable for the development of effective and targeted agrochemicals.
Used in Organic Synthesis:
1H-Indene, 6-bromoserves as a key intermediate in organic synthesis, enabling the creation of more complex organic compounds for various applications, including the development of new materials and the synthesis of novel chemical entities.
Used as a Reagent in Chemical Reactions:
In research and industrial settings, 1H-Indene, 6-bromomay be used as a reagent in chemical reactions. Its bromine atom can participate in various reaction mechanisms, facilitating the synthesis of desired products and contributing to the advancement of chemical research and development.

Upstream product

• 64-17-5 ethanol 
• 34598-49-7 5-Bromo-1-indanone 
• 67-56-1 methanol 

Downstream Products

• 34784-05-9 6-bromo-isoquinoline 
• 14548-39-1 6-bromoindan-1-one 
• 848760-75-8 6-[4'-(hydroxymethyl)phenyl]-1H-indene 
• 75476-86-7 6-Bromo-2,3-dihydro-1H-inden-1-ol 
• 75476-78-7 5-bromo-1H-indene 
• 679433-92-2 6-ethylisoquinoline 

Relevant academic research and scientific papers

Selective alkylation and Suzuki coupling as an efficient strategy for introducing functional anchors to the ethylene-bis(indenyl) ligand

Chiral ansa-ethylene-bis(indenyl)-metal complexes, EBI-MX2, are useful pre-catalysts for a wide variety of reactions, including hydrogenations, hydrosilylations, and polymerization reactions. In order to immobilize these complexes onto heterogeneous supports, a new methodology was developed to introduce functional anchors to the ethylene-bis(indenyl) ligand, EBI. This was accomplished by selective alkylation of indene to form toluene-4-sulfonic acid 2-(3H-inden-1-yl)-ethyl ester, which was then used to alkylate 6-bromoindene. The selective introduction of an aryl bromide then undergoes coupling reactions with aryl borates via the Suzuki coupling to efficiently introduce an alkenyl or alcohol, functional anchor in a simple four step synthesis.

Solvolysis Mechanism of Indan-2-yl Arenesulfonates

The solvolysis rates of 5-(Y)-substituted indan-2-yl (Z)-benzenesulfonates were determined in a variety of protic solvents at 45.0, 55.0 and 65.0 deg C.Application of an extended Grunwald-Winstein equation indicates that kinetic responses to both solvent ionizing power, YOTs, and solvent nucleophilicity, NOTs, are relatively low but increase in parallel with increasing leaving ability, m = 0.39-0.46 and I=0.32-0.41 for Z=p-Me p-NO2.The magnitude of cross-interaction constant, ρYZ, is also relatively small (0.16-0.32), which is, however, much more dependent on the nucleophilicity rather than the ionizing power of the solvent.These are consistent with the typical SN2 mechanism proceeding through a transition state in which solvent participates in both bond-making and -breaking processes.