330785-85-8

Basic information

• Product Name: 5-Pyrimidinemethanol, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(methylthio)-
• Synonyms: (4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidin-5-yl)methanol
• CAS NO: 330785-85-8
• Molecular Formula: C14H16ClN3O2S
• Molecular Weight: 325.819
• Mol File: 330785-85-8.mol

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinemethanol, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(methylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinemethanol, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(methylthio)-(330785-85-8)
• EPA Substance Registry System: 5-Pyrimidinemethanol, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-(methylthio)-(330785-85-8)

Safety Data

• Hazardous Substances Data: 330785-85-8(Hazardous Substances Data)

Upstream product

• 330785-81-4 ethyl 4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylate 
• 108-20-3 di-isopropyl ether 

Downstream Products

• 330785-86-9 4-(3-Chloro-4-methoxy-benzylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde 

Relevant articles and documents

Cyclic compounds

1. A cyclic compound of the formula (I) or a pharmacologically acceptable salt thereof, wherein X is ═CH— or ═N—, Y is —NH—, —NR4—, —S—, —O—, —CH═N—, —N═CH—, —N═N—, —CH═CH—, etc., R1 is a lower alkoxy group, an amino group, a heterocyclic ring containing N atom(s), or a hydroxy group substituted by a heterocyclic ring containing N atom(s) (each of which is optionally substituted), R2 is a lower alkylamino group which is optionally substituted by an aryl group, a lower alkoxy group which is optionally substituted by an aryl group, a lower alkoxy group substituted by an aromatic heterocyclic ring containing N atom(s), R3 is an aryl group, a heterocyclic ring containing N atom(s), a lower alkyl group, a lower alkoxy group, a cyclo lower alkoxy group, a hydroxy group substituted by a heterocyclic ring containing N atom(s), or an amino group (each of which is optionally substituted), and R3 and a substituent in Y may be combined to form a lactone ring. The compound of the present invention has excellent selective PDE V inhibitory activity and therefore, is useful as a therapeutic or prophylactic drug for treating various diseases due to functional disorders on cGMP-signaling.

Aromatic nitrogen-containing 6-membered cyclic compounds

An aromatic nitrogen-containing 6-membered cyclic compound of the formula (I): wherein Ring A is a substituted or unsubstituted nitrogen-containing heterocyclic group; R1 is a substituted or unsubstituted lower alkyl group, —NH—Q—R3 (R3 is a substituted or unsubstituted nitrogen containing heterocyclic group, and Q is a lower alkylene group or a single bond), or —NH—R4 (R4 is a substituted or unsubstituted cycloalkyl group); R2 is a substituted or unsubstituted aryl group; one of Y and Z is ═CH—, and the other is ═N—, or a pharmaceutically acceptable salt thereof, these compounds exhibiting excellent selective PDE V inhibitory activities, and hence, being useful in the prophylaxis or treatment of penile erectile dysfunction, etc.

PYRIDOPYRIMIDINE OR NAPHTHYRIDINE DERIVATIVE

A pyridopyrimidine or a naphthyridine derivative of the formula (I): wherein R1 is an optionally substituted nitrogen-containing heterocyclic group, etc.; R2 is H or a lower alkyl group; R3 is H or an optionally substitute