33143-44-1

Upstream product

• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 100-52-7 benzaldehyde 
• 57813-28-2 β-hydroxyethyltriphenylarsonium bromide 
• 5650-34-0 2,3-epoxy-1-phenylpropan-1-one 
• 1086229-91-5 C₁₄H₁₈O₃ 
• 100-51-6 benzyl alcohol 
• 31814-66-1 Phenyl-((R)-3-trimethylsilanyl-oxiranyl)-methanol 
• 21087-29-6 trans-3-phenylprop-2-enyl chloride 
• 31930-44-6 (Z)-1-phenyl-3-(trimethylsilyl)prop-2-en-1-ol 

Downstream Products

• 203924-91-8 1-phenyl-1-(prop-2-ynyloxy)-2,3-epoxypropane 
• 5650-34-0 2,3-epoxy-1-phenylpropan-1-one 
• 847832-73-9 2-[(2-chloro-5-methyl-phenoxy)-phenyl-methyl]-oxirane 
• 579-07-7 1-Phenylpropane-1,2-dione 
• 104-54-1 3-Phenylpropenol 
• 7217-71-2 1-phenyl-2-propenyl acetate 
• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 104713-12-4 (1S)-1-phenylprop-2-en-1-ol 
• 63157-81-3 1-phenyl-propane-1,2,3-triol 
• 146388-55-8 (1R,2R)-2,3-epoxy-1-phenylpropan-1-ol 

Relevant academic research and scientific papers

Introducing aldehyde functionality to proteins using ligand-directed affinity labeling

Aldehyde is a versatile chemical handle for protein modification. Although many methods have been developed to label proteins with aldehyde, target-specific methods amenable to endogenous proteins are limited. Here, we report a simple affinity probe strategy to introduce aldehydes to native proteins. Notably, the probe contains a latent aldehyde functionality that is only exposed upon target binding, thereby enabling a one-pot labeling procedure.

AMINOPYRROLOTRIAZINES AS KINASE INHIBITORS

The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.

Chiral Manganese Aminopyridine Complexes: the Versatile Catalysts of Chemo- and Stereoselective Oxidations with H2O2

In the last decade, manganese(II) complexes with N-donor tetradentate aminopyridine ligands emerged as efficient catalysts of enantioselective epoxidation of olefins and direct selective oxidation of C?H groups in complex organic molecules, with environmentally benign oxidant hydrogen peroxide. In this personal account, we summarize the progress of these catalysts with regard to ligands design, structure-reactivity correlations, evaluation of the substrate scope, as well as mechanistic studies, shedding light on the nature of active sites and the mechanisms of selective oxygenations. Several practically promising catalytic syntheses with the aid of Mn aminopyridine catalysts are exemplified.

Green Organocatalytic Dihydroxylation of Alkenes

An inexpensive, green, metal-free one-pot procedure for the dihydroxylation of alkenes is described. H2O2 and 2,2,2-trifluoroacetophenone were employed as the oxidant and organocatalyst, respectively, in this highly sustainable protocol in which a variety of homoallylic alcohols, aminoalkenes, and simple alkenes were converted into the corresponding polyalcohols in good to excellent yields. This process takes advantage of an epoxidation reaction followed by an acidic treatment in which water participates in the ring opening of the in situ prepared epoxide to lead to the desired product.

Titanocene(III) chloride mediated radical induced addition-elimination route to the synthesis of racemic and optically active trisubstituted tetrahydrofurans: Formal synthesis of magnofargesin and 7’-epimagnofargesin

Titanocene(III) Chloride mediated radical induced synthesis of 4-benzylidene substituted tetrahydrofuran, a typical lignan skeleton, has been accomplished in good yield through addition-elimination route in racemic as well as in optically active forms. The method has been applied to the synthesis of furano lignans, magnofargesin (1) and 7’-epimagnofargesin (2) in optically active forms.

Titanocene(III) chloride mediated radical-induced opening of monosubstituted epoxy acetates for the synthesis of primary allylic alcohols

A simple and efficient method for the synthesis of primary allylic alcohols from monosubstituted epoxy acetates has been developed using titanocene(III) chloride mediated epoxide ring opening via acetate elimination.

Highly diastereo- and enantio-selective epoxidation of secondary allylic alcohols catalyzed by styrene monooxygenase

Enantiomerically enriched glycidol derivatives with contiguous stereogenic centers were obtained in a highly diastereo- and enantio-selective epoxidation catalyzed with the styrene monooxygenase StyAB2.

Indium-promoted chemo- and diastereoselective allylation of α,β-epoxy ketones with potassium allyltrifluoroborate

A practical method for the chemo- and diastereoselective allylation of α,β-epoxy ketones has been developed by using the convenient air and moisture stable reagent potassium allyltrifluoroborate. Indium metal was found to promote addition in stoichiometric or catalytic amounts, to afford α,β-epoxyhomoallylic tertiary alcohols in high yields and diastereoselectivities, without competing ring-scission of the epoxide.

Kinetic solvent effects on peroxyl radical reactions

Kinetic solvent effects on peroxyl radical reactions are easily determined using a new peroxyester-based radical clock method. The Royal Society of Chemistry.

Highly enantioselective synthesis of β-amino alcohols: A catalytic version

(Chemical Equation Presented) Highly enantioselective rearrangement of β-amino alcohols was realized by using a catalytic amount of trifluoroacetic anhydride.