33192-00-6

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(4-chlorophenyl)-2-(phenylthio)is used as a pharmaceutical intermediate for its potential biological activity. Ethanone, 1-(4-chlorophenyl)-2-(phenylthio)-'s unique structure, including the chloro substituent and thioether linkage, may contribute to its efficacy in drug development, particularly in the synthesis of new therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, Ethanone, 1-(4-chlorophenyl)-2-(phenylthio)is utilized as a precursor in the synthesis of agrochemicals. Its chemical properties, including the presence of the ketone group and the thioether linkage, make it a valuable component in the creation of pesticides or other agricultural chemicals.
Used in Materials Science:
Ethanone, 1-(4-chlorophenyl)-2-(phenylthio)is employed in materials science for its potential to influence the physical and chemical properties of various materials. Ethanone, 1-(4-chlorophenyl)-2-(phenylthio)-'s structure, with its ketone and thioether groups, may be integrated into the development of new materials with specific characteristics, such as improved stability or reactivity.
Used in Chemical Research:
As a research chemical, Ethanone, 1-(4-chlorophenyl)-2-(phenylthio)is used to explore its reactivity and properties in various chemical reactions. Understanding how Ethanone, 1-(4-chlorophenyl)-2-(phenylthio)- interacts with other chemicals can lead to the discovery of new reaction pathways and the development of novel compounds with diverse applications.

Upstream product

• 108-98-5 thiophenol 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 99-91-2 para-chloroacetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 111198-03-9 1-((phenylthio)methyl)-1H-benzo[d][1,2,3]triazole 
• 930-69-8 sodium thiophenolate 
• 96928-08-4 2-[2-(4-Chloro-phenyl)-2-oxo-ethylsulfanyl]-1-methyl-4,6-diphenyl-pyridinium; bromide 

Downstream Products

• 1235497-46-7 6-(4-chlorophenyl)-4-[4-(dimethylamino)phenyl]-2-ethoxy-5-(phenylsulfanyl)nicotinonitrile 
• 1380501-74-5 2-(4-chlorophenyl)-4-hexylfuran 
• 1380501-87-0 4-(5-(4-chlorophenyl)furan-3-yl)butyl pivalate 
• 69602-25-1 ((4-chlorophenyl)ethynyl)(phenyl)sulfane 
• 1363159-06-1 (S)-1-(4-chlorophenyl)-2-(phenylthio)ethanol 
• 1260255-29-5 C₂₈H₂₂Cl₂N₂S₂ 
• 63216-03-5 1-(4-Chloro-phenyl)-2-(4-methoxy-phenyl)-2-phenylsulfanyl-ethanone 
• 153235-59-7 6-(4-Chloro-phenyl)-3-phenyl-7-phenylsulfanyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 153235-57-5 6-(4-Chloro-phenyl)-3-methyl-7-phenylsulfanyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 58936-71-3 ω-Phenylsulfinyl-p-chloracetophenon 

Relevant academic research and scientific papers

Catalytic Asymmetric [4 + 1] Annulation of Sulfur Ylides with Copper-Allenylidene Intermediates

The first copper-catalyzed asymmetric decarboxylative [4 + 1] cycloaddition of propargylic carbamates and sulfur ylides was successfully developed. This strategy led to a series of chiral indolines with synthetically flexible alkyne groups in good yields and with high enantio- and diastereoselectivities (up to 99% yield, 98% ee, and >95:5 dr). A possible mechanism and stereoinduction mode with copper-allenylidenes were proposed as the possible dipolar intermediate.

One-pot preparation of arylethynyl sulfides and bis(arylethynyl) sulfides

An efficient preparation for arylethynyl sulfides 1 and bis(arylethynyl) sulfides 2 has been accomplished through a one-pot, three-step strategy that starts from arylethanonyl sulfides and bis(arylethanonyl) sulfides, respectively, without the use of various terminal arylacetylenes as substrates. When lithium hexamethyldisilazane (LHMDS), ClP(O)(OEt)2, and LHMDS were sequentially added to a tetrahydrofuran solution of different substrates [arylethanonyl sulfides or bis(arylethanonyl) sulfides], 1 or 2 were obtained in moderate to good yields. The reaction procedure involves the formation of an enol phosphate and a subsequent base-induced elimination. An efficient preparation of arylethynyl sulfides 1 and bis(arylethynyl) sulfides 2 has been accomplished by a one-pot, three-step strategy that starts from arylethanonyl sulfides and bis(arylethanonyl) sulfides, respectively, to give 1 and 2 in moderate to good yields. The reaction mechanism involves the formation of an enol phosphate that undergoes a subsequent base-induced elimination. Copyright

Gold-catalyzed carbene transfer to alkynes: Access to 2,4-disubstituted furans

Furans of gold: The first example of a gold-catalyzed intermolecular addition of carbon ylides to terminal alkynes is reported (see scheme; DCE=dichloroethane, Tf=trifluoromethanesulfonyl). Subsequent intramolecular trapping of the generated gold carbene completes a formal [3+2] cycloaddition, which represents a novel synthesis of 2,4-disubstituted furans. Copyright

Selective one-pot multicomponent synthesis and anti-tubercular evaluation of 5-(aryl/cyclohexylsulfanyl)-2-alkoxy-4,6-diarylnicotinonitriles

A new set of highly substituted pyridine derivatives has been synthesized by a product selective four component reaction of aryl aldehyde, malononitrile and 2-aryl/cyclohexylsulfanyl-1-aryl-1-ethanones in presence of sodium hydroxide in methyl/ethyl alcoh

Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity

Azines derived from substituted phenacyl aryl/cyclohexyl sulfide on treatment with excess phosphorous oxychloride in N,N-dimethylformamide have been found to yield two isomeric pyrazoles in each case. A plausible mechanism has been suggested for the forma

Novel and efficient insertions of carbons carrying O-, S-, and N-Linked substituents: Synthesis of α-alkoxyalkyl, α-(Alkylthio)alkyl, and α-(Carbazol-9-yl)alkyl ketones

A wide variety of benzotriazolyl-stabilized anions 2, obtained by the lithiation of 1-(α-alkoxyalkyl)-, 1-[α-(alkylthio)alkyl]-, and 1-[α-(carbazol-9-yl)alkyl]benzotriazoles 1, on reaction with aliphatic and aromatic aldehydes and ketones, followed by rearrangement induced by heating in the presence of zinc bromide, furnish one-carbon-homologated α-alkoxyalkyl, α-(alkylthio)alkyl, and α-(carbazol-9-yl)alkyl ketones 4 in simple one-pot operations in good yields with excellent regioselectivity. In several alkoxymethylene insertions, intermediate 2-alkoxyoxiranes were separated in good yields, demonstrating the epoxide mechanism for the rearrangements and providing a facile approach to poly substituted 2-alkoxyoxiranes, another class of important compounds.

Synthesis Using Pyridinium Anhydrobases. Preparation of Indolizine Derivatives

A number of derivatives of indolizine ring system have been prepared from 1-substituted 4,6-diphenyl-2-phenacylidene-1,2-dihydropyridines either by metallation with LDA or acylation and further basic treatment.Similarly, 1-arylmethyl-4,6-diphenyl-2-dicyanomethylene-1,2-dihydropyridines by action of LDA undergo cyclization to the corresponding 2-amino-1-cyano-3-aryl indolizinies.

2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents

Derivatives of 2-phenyl-3-aroylbenzothiophenes and 2-phenyl-3-aroylbenzothiophene-1-oxides are useful as antifertility agents. Certain of these compounds also are useful in suppressing the growth of mammary tumors.