332-29-6

Basic information

• Product Name: 2-(4-fluorophenyl)acetamide
• Synonyms: 2-(4-fluorophenyl)acetamide
• CAS NO: 332-29-6
• Molecular Weight: 153.156
• Mol File: 332-29-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)acetamide(332-29-6)
• EPA Substance Registry System: 2-(4-fluorophenyl)acetamide(332-29-6)

Safety Data

• Hazardous Substances Data: 332-29-6(Hazardous Substances Data)

Usage

General Description

2-(4-fluorophenyl)acetamide is a chemical compound with the molecular formula C8H8FNO. It is an amide derivative of acetaminophen, which is commonly used as a pain reliever and fever reducer. The presence of a fluorine atom on the phenyl ring gives 2-(4-fluorophenyl)acetamide distinct properties, potentially affecting its solubility, stability, and reactivity compared to other acetamide derivatives. This chemical may have potential applications in the pharmaceutical industry as a building block for the synthesis of new drugs or as a research tool in medicinal chemistry studies. Further research may be warranted to better understand the specific properties and potential uses of 2-(4-fluorophenyl)acetamide.

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 459-04-1 4-Fluorophenylacetyl chloride 
• 459-22-3 4-fluorophenylacetonitrile 
• 405-50-5 p-Fluorophenylacetic acid 

Downstream Products

• 18166-64-8 4-chlorocinnamide 
• 77418-82-7 4-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-piperidine-2,6-dione 
• 587-88-2 ethyl 2-(4-fluorophenyl)acetate 
• 934560-45-9 2-(4-fluorophenyl)-N-(2-isonicotinoylphenyl)acetamide 
• 1208065-62-6 C₁₇H₁₂FNO₂S 
• 1459775-50-8 3-(4-fluoro-phenyl)quinolin-2(1H)-one 
• 7589-27-7 2-(4-Fluorophenyl)ethanol 
• 89080-92-2 3-(4-fluorophenyl)-4-methylquinolin-2(1H)-one 
• 861393-61-5 N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dimethylpropyl]-2-(4-fluorophenyl)acetamide 

Relevant articles and documents

Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration, and α-Deuterated Amide Formation via Metal Ligand Cooperation

A simple and efficient system for the hydration and α-deuteration of nitriles to form amides, α-deuterated nitriles, and α-deuterated amides catalyzed by a single pincer complex of the earth-abundant manganese capable of metal-ligand cooperation is reported. The reaction is selective and tolerates a wide range of functional groups, giving the corresponding amides in moderate to good yields. Changing the solvent from tert-butanol to toluene and using D2O results in formation of α-deuterated nitriles in high selectivity. Moreover, α-deuterated amides can be obtained in one step directly from nitriles and D2O in THF. Preliminary mechanistic studies suggest the transformations contributing toward activation of the nitriles via a metal-ligand cooperative pathway, generating the manganese ketimido and enamido pincer complexes as the key intermediates for further transformations.

Synthesis of aryl anilinomaleimide based derivatives as glycogen synthase kinase-3β inhibitors with potential role as antidepressant agents

A series of aryl anilinomaleimide based derivatives has been synthesized and evaluated for in vitro glycogen synthase kinase-3β (GSK-3β) inhibitory activity. A large number of compounds from the series exhibited moderate to potent inhibitory activity against GSK-3β, with more than one-third of the compounds showing inhibition with IC50 values 50 values of 0.09, 0.12, 0.17, 0.19, 0.21 and 0.23 μM respectively), were further investigated for antidepressant activity by the widely accepted forced swim test and tail suspension test (FST and TST) models. All the tested compounds displayed antidepressant-like effects, particularly compounds 8j and 8b, which exhibited significant antidepressant activity, about 1.4-fold higher than fluoxetine, a standard antidepressant drug in both FST and TST. Preliminary structure-activity relationships have also been generated based on the experimental data obtained.

CYCLOPROPANE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES

Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including, but not limited to, malignant melanomas, solid tumors, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, chronic myelogenous leukemia, leukemias, papillary thyroid carcinoma, non-small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, diabetic retinopathy, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, and diseases caused by PDGFR-α kinase, PDGFR-β kinase, c-KIT kinase, cFMS kinase, c-MET kinase, and oncogenic forms, aberrant fusion proteins and polymorphs of any of the foregoing kinases.