33238-63-0

Usage

Uses

Used in Pharmaceutical Research and Development:
4(3H)-PYRIMIDINONE, 5-BROMO-6-METHYL-2-(METHYLTHIO)is used as a building block for the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure and functional groups contribute to the development of novel therapeutic agents with potential applications in treating various diseases and conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 4(3H)-PYRIMIDINONE, 5-BROMO-6-METHYL-2-(METHYLTHIO)serves as a versatile intermediate for the preparation of a wide range of organic compounds. Its reactivity and functional groups enable chemists to carry out various chemical reactions, leading to the formation of diverse molecular structures with potential applications in various industries.
Used in Anti-inflammatory Applications:
4(3H)-PYRIMIDINONE, 5-BROMO-6-METHYL-2-(METHYLTHIO)exhibits anti-inflammatory properties, making it a promising candidate for the development of anti-inflammatory drugs. It can be used as an active pharmaceutical ingredient or a key intermediate in the synthesis of other anti-inflammatory agents, offering potential therapeutic benefits in the treatment of inflammation-related disorders.
Used in Antimicrobial Applications:
Due to its antimicrobial properties, 4(3H)-PYRIMIDINONE, 5-BROMO-6-METHYL-2-(METHYLTHIO)can be employed in the development of antimicrobial agents to combat bacterial, fungal, and viral infections. It can be used as a standalone antimicrobial compound or as a component in the synthesis of more complex antimicrobial drugs, contributing to the fight against antibiotic resistance and the discovery of novel antimicrobial therapies.

InChI:InChI=1/C6H7BrN2OS/c1-3-4(7)5(10)9-6(8-3)11-2/h1-2H3,(H,8,9,10)

Upstream product

• 56-04-2 2-mercapto-6-methylpyrimidin-4(3H)-one 
• 56-04-2 6-methyl-2-thiouracil 
• 98027-28-2 5-bromo-6-methyl-2-thiouracil 
• 74-88-4 methyl iodide 
• 6328-58-1 6-methyl-2-methylsulfanyl-3H-pyrimidin-4-one 

Downstream Products

• 408336-06-1 4-(4-chloro-anilino)-6-methyl-1H-pyrimidin-2-one 
• 56745-01-8 5-bromo-2,4-dichloro-6-methylpyrimidine 
• 5424-21-5 2,4-dichloro-6-methylpyrimidine 
• 13036-57-2 2-chloro-4-methylpyrimidine 
• 17119-74-3 5-bromo-4-chloro-6-methyl-2-(methylthio)pyrimidine 
• 15018-56-1 5-bromo-6-methyluracil 
• 23948-46-1 5-bromo-2-(4-chloro-anilino)-6-methyl-3H-pyrimidin-4-one 

Relevant academic research and scientific papers

Unified Synthetic Approach to 2-Substituted 6-Methylisocytosines and Their 5-Bromo Derivatives

6-Methyl-4(3H)-pyrimidinones containing 2-alkyl-, 2-cycloalkyl-, and 2-arylalkylamino groups were synthesized and brominated to obtain 5-bromo derivatives.

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies

Phenotypic screening of a Medicines for Malaria Venture compound library against Mycobacterium tuberculosis (Mtb) identified a cluster of pan-active 2-pyrazolylpyrimidinones. The biology triage of these actives using various tool strains of Mtb suggested a novel mechanism of action. The compounds were bactericidal against replicating Mtb and retained potency against clinical isolates of Mtb. Although selected MmpL3 mutant strains of Mtb showed resistance to these compounds, there was no shift in the minimum inhibitory concentration (MIC) against a mmpL3 hypomorph, suggesting mutations in MmpL3 as a possible resistance mechanism for the compounds but not necessarily as the target. RNA transcriptional profiling and the checkerboard board 2D-MIC assay in the presence of varying concentrations of ferrous salt indicated perturbation of the Fe-homeostasis by the compounds. Structure-activity relationship studies identified potent compounds with good physicochemical properties and in vitro microsomal metabolic stability with moderate selectivity over cytotoxicity against mammalian cell lines.

REACTIONS WITH 6-METHYL-2-THIOURACIL SYNTHESIS OF DIPYRIMIDINOTHIAZINE. A NEW RING SYSTEM

Bromination of 6-methyl-2-thiouracil (I) gave the 5-bromo analogue II.Alkylation of each of I and II yielded the S-alkyl derivatives IIIa-g.Cyclisation of IIIa,c gave the 3,7-dimethylthiazolopyrimidines VIIa,b.The 2-arylmethylenethiazolopyri