332902-05-3Relevant academic research and scientific papers
Isocyanate stabilizer and preparation method thereof
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Paragraph 0055; 0056; 0057, (2018/06/21)
The invention relates to an isocyanate stabilizer and a preparation method thereof, aiming at inhibiting yellowing and turbidity phenomena caused by the fact that isocyanate is in contact with water and oxygen in a downstream utilization process. The isoc
Synthesis of Benzyl Amines via Copper-Catalyzed Enantioselective Aza-Friedel-Crafts Addition of Phenols to N -Sulfonyl Aldimines
Shikora, Jonathan M.,Chemler, Sherry R.
, p. 2133 - 2137 (2018/04/30)
A new copper-catalyzed enantioselective aza-Freidel-Crafts reaction between phenols and N-sulfonyl aldimines that provides chiral secondary benzylamines in good to excellent yields and excellent enantioselectivities (up to 99% ee) is disclosed. In particular, excellent scope with alkylimines was observed for the first time. The synthetic utility of the products was demonstrated in the first enantioselective synthesis of a dual orexin receptor antagonist, a compound that contains an amine-bearing stereocenter adjacent to a bis-ortho-functionalized arene.
Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines
Kato, Naoya,Shirai, Tomohiko,Yamamoto, Yasunori
supporting information, p. 7739 - 7742 (2016/06/09)
Chiral rhodium(I)-catalyzed highly enantioselective arylation of aliphatic N-sulfonyl aldimines with arylboronic acids has been developed. This transformation is achieved by the use of a rhodium/bis(phosphoramidite) catalyst to give enantiomerically enriched α-branched amines (up to 99 % ee). In addition, this system enables efficient synthesis of (+)-NPS R-568 and Cinacalcet which are calcimimetic agents.
Direct Synthesis of Hemiaminal Ethers via a Three-Component Reaction of Aldehydes, Amines and Alcohols
Beltrán, álvaro,álvarez, Eleuterio,Díaz-Requejo, M. Mar,Pérez, Pedro J.
supporting information, p. 2821 - 2826 (2015/09/28)
The reaction of aldehydes, amines and alcohols usually leads to a series of equilibria from which isolation of one product is difficult to achieve. We have found that this three-component reaction can be controlled and directed in an exclusive manner toward the formation of the hemiaminal ether. A series of 33 hemiaminal ethers has been obtained in high yields, from different aldehydes, amines and alcohols, under very mild conditions just with molecular sieves as promoter.
A new method for preparation of 3,6-dihydro-2H-1,3-oxazines and explorations of their use in stereoselective synthesis of 1,3-amino alcohol derivatives
Cherkauskas, John P.,Klos, Andrew M.,Borzilleri, Robert M.,Sisko, Joseph,Weinreb, Steven M.,Parvez, Masood
, p. 3135 - 3152 (2007/10/03)
Condensation of β-hydroxy aldehydes with N-sulfonyl aldimines produces 3,6-dihydro-2H-1,3-oxazines in moderate to excellent yields. The process is stereoselective, with the C-2 and C-6 substituents having a trans relationship in these heterocycles. Some transformations of these oxazines as potential acyclic 1,3-amino alcohol synthons are described.
