135097-23-3

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S)-
• Synonyms: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S)-;(S)-1-TERT-BUTYL 2-ETHYL PYRROLIDINE-1,2-DICARBOXYLATE
• CAS NO: 135097-23-3
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.29944
• Mol File: 135097-23-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 305.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.100±0.06 g/cm3(Predicted)
• PKA: -3.22±0.40(Predicted)
• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S)-(135097-23-3)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S)-(135097-23-3)

Safety Data

• Hazardous Substances Data: 135097-23-3(Hazardous Substances Data)

Usage

General Description

1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S)- is a chemical compound with the molecular formula C12H23NO4. It is a derivative of pyrrolidine carboxylic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a chiral molecule, meaning it has a distinct three-dimensional structure, and is often used in the production of enantiomerically pure compounds. Additionally, it has potential applications in the field of organic chemistry and drug development due to its unique structural properties and stereochemistry.

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 64-17-5 ethanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5817-26-5 ethyl (2S)-pyrrolidine-2-carboxylate 
• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 
• 147-85-3 L-proline 
• 33305-75-8 L-proline ethyl ester monohydrochloride 
• 194594-23-5 5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 75-03-6 ethyl iodide 

Downstream Products

• 33305-75-8 L-proline ethyl ester monohydrochloride 
• 1621482-38-9 1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)pyrrolidine-1,2-dicarboxylate 
• 1194030-71-1 2-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid 
• 1621435-28-6 tert-butyl 2-((2S, 3R)-1, 3-bis (benzyloxy)-1-oxobutan-2-yl)-1-oxo-2, 5-diazaspiro [3.4] octane-5-carboxylate 
• 1621435-13-9 tert-butyl 2-(((2S, 3R)-1, 3-bis (benzyloxy)-1-oxobutan-2-yl) carbamoyl)-2-(hydroxymethyl) pyrrolidine-1-carboxylate 
• 92235-33-1 (S)-tert-butyl 2-(benzylcarbamoyl)pyrrolidine-1-carboxylate 
• 86661-32-7 (S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate 
• 135055-76-4 (S)-1-[(E)-3-(4-tert-Butyl-phenyl)-2-methyl-propenyl]-2-[(diphenylphosphanyl)-methyl]-pyrrolidine 
• 135055-75-3 (S)-(-)-N-tert-butoxycarbonyl-2-<(diphenylphosphino)methyl>pyrrolidine 
• 135055-77-5 (S)-2-[(Diphenylphosphanyl)-methyl]-1-((E)-2-methyl-but-1-enyl)-pyrrolidine 
• 130203-08-6 (E)-3-{(S)-2-[(Diphenylphosphanyl)-methyl]-pyrrolidin-1-yl}-2-methyl-but-2-enoic acid tert-butyl ester 
• 130203-07-5 (E)-3-{(S)-2-[(Diphenylphosphanyl)-methyl]-pyrrolidin-1-yl}-2-methyl-but-2-enoic acid ethyl ester 
• 130203-11-1 (S)-2-[(Diphenylphosphanyl)-methyl]-1-((Z)-2-phenyl-propenyl)-pyrrolidine 
• 130203-12-2 (S)-1-Cyclohex-1-enyl-2-[(diphenylphosphanyl)-methyl]-pyrrolidine 

Relevant articles and documents

ANTIVIRAL COMPOUNDS

The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.

Cobalt-Catalyzed Esterification of Amides

The first cobalt-catalyzed amide activation of N-Boc-amides, and their conversion into esters, is reported here. This new methodology presents a very practical process that does not require an inert atmosphere, uses an inexpensive cobalt catalyst, and proceeds under mild reaction conditions. This catalytic system has a broad substrate scope and has been shown to be highly efficient, with catalyst loadings as low as 1 mol %.

One-pot transformation of carboxylic acids into nitriles

A variety of aromatic and aliphatic carboxylic acids were smoothly converted into the corresponding nitriles in good yields in a one-pot procedure by treatment with ethyl iodide/K2CO3/18-crown-6, followed by sodium diisobutyl-tert-butoxyaluminium hydride (SDBBA-H), and finally treatment with molecular iodine or 1,3-diiodo-5,5-dimethylhydantoin (DIH), and aqueous ammonia. This method is useful for the conversion of various aromatic and aliphatic carboxylic acids into the corresponding nitriles in a one-pot procedure. A variety of aromatic and aliphatic carboxylic acids were smoothly converted into the corresponding nitriles in good yields in a one-pot procedure by treatment with ethyl iodide/K2CO3/18-crown-6, followed by sodium diisobutyl-tert-butoxyaluminium hydride (SDBBA-H), and finally treatment with molecular iodine or 1,3-diiodo-5,5-dimethylhydantoin (DIH), and aqueous ammonia. Copyright