33313-70-1

Upstream product

• 108-95-2 phenol 
• 32833-70-8 4-phenoxybut-2-yn-1-ol 
• 13610-02-1 1-phenoxy-2-propyne 
• 79-22-1 methyl chloroformate 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 32978-41-9 4-phenoxy-2-butynoic acid 

Downstream Products

• 1062227-01-3 C₁₆H₁₆O₃ 

Relevant academic research and scientific papers

PtIV-catalyzed cyclization of arene-alkyne substrates via intramolecular electrophilic hydroarylation

(Figure presented) We herein report that PtCl4 has proven to be a hydroarylation catalyst with an efficiency and substrate scope superior to previously known methods. This catalyst demonstrated consistent performance with arene-yne substrates of diverse structural features, including propargyl ethers, propargylamines, and alkynoate esters, providing good to excellent yields of the 6-endo products (chromenes, dihydroquinolines, and coumarins). In contrast, Pt(II), Pd(II), and Ga(III) salts were shown to be sensitive to the substitution on the alkyne moiety.

FACILE SYNTHESIS OF ACETYLENECARBOXYLATES BY THE OXIDATIVE CARBONYLATION OF TERMINAL ACETYLENES CATALYSED BY PdCl2 UNDER MILD CONDITIONS

Terminal acetylenes were converted to acetylenecarboxylates in high yields under athmospheric pressure of carbon monoxide at room temperature using a catalytic amount of PdCl2 and a stoichiometric amount of CuCl2.