33322-95-1

Upstream product

• 631-61-8 ammonium acetate 
• 141-97-9 ethyl acetoacetate 
• 504-02-9 1,3-cylohexanedione 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1403363-46-1 C₂₀H₂₃NO₄ 
• 1403363-44-9 C₂₀H₂₃NO₄ 
• 94685-47-9 4-(4-methoxy-phenyl)-2-methyl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

1, 3-Disulfonic acid imidazolium hydrogen sulphate as an efficient and reusable ionic liquid for the multicomponent synthesis of polyhydroquinoline derivatives under solvent-free conditions

A facile and highly effective one-pot synthesis of polyhydroquinoline derivatives is reported via Hantzsch condensation of aldehydes, 1,3-dicarbonyl compounds, ethyl acetoacetate, and ammonium acetate in the presence of 1,3-disulfonic acid imidazolium hyd

Synthesis of MCM-41 supported cobalt (II) complex for the formation of polyhydroquinoline derivatives

A new and green heterogeneous MCM-41@PDCA-Co catalyst has been prepared via immobilization of cobalt (II) complex onto the surface of MCM-41. This was characterized by different techniques such as FT-IR, TEM, TGA, low angle Powder XRD, MP-AES and nitrogen

Synthesis and characterization of homobimetallic molybdenum(VI) complexes of a dihydrazone as efficient catalysts for the synthesis of hexahydroxyquinolines via multicomponent Hantzsch reaction

Four homobimetallic molybdenum(VI) complexes [(MoO2)2L(D)2] (1–4) (where D = methanol (1), dimethylsufoxide (2), imidazole (3) and pyridine (4)) derived from a multidentate hydrazone ligand, 1,4-bis(3-ethoxy-2-hydroxybenza

Cellulose matrix embedded copper decorated magnetic bionanocomposite as a green catalyst in the synthesis of dihydropyridines and polyhydroquinolines

A new biopolymer-based magnetic nanocomposite was prepared and characterized by Fourier transform infrared (FT-IR) spectroscopy, energy-dispersive X-ray (EDX) analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images,

Surface modified SPIONs-Cr(VI) ions-immobilized organic-inorganic hybrid as a magnetically recyclable nanocatalyst for rapid synthesis of polyhydroquinolines under solvent-free conditions at room temperature

In this work, a magnetic hybrid dichromate nanocomposite with triphenylphosphine surface modified superparamagnetic iron oxide nanoparticles (SPIONs) as a recyclable nanocatalyst was designed, prepared and characterized by Fourier transform infrared spect

Introduction of a novel nanosized N-sulfonated Br?nsted acidic catalyst for the promotion of the synthesis of polyhydroquinoline derivatives via Hantzsch condensation under solvent-free conditions

In this research 4,4′-(butane-1,4-diyl)bis(1-sulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium)tetrachloride (NS-C4(DABCO-SO3H)2)·4Cl) as a new nano sized N-sulfonic acid was prepared and characterized using different types of methods including FT-IR, 1H NMR, 13C NMR, mass, XRD, TGA, SEM and AFM analysis. After the characterization of this reagent, it was efficiently used for the promotion of the one-pot synthesis of hexahydroquinolines via one-pot four-component condensation of aryl aldehydes, 1,3-cyclohexadione derivatives, β-ketoesters and ammonium acetate under solvent-free conditions. The procedure gave the products in excellent yields in short reaction times and good to high yields. Also this catalyst can be reused several times without loss of its catalytic activity.

Nano-zirconia as an excellent nano support for immobilization of sulfonic acid: A new, efficient and highly recyclable heterogeneous solid acid nanocatalyst for multicomponent reactions

Nano-zirconia-supported sulfonic acid [nano-ZrO2-SO3H (n-ZrSA)] is synthesized by immobilizing sulfonic acid groups on the surface of nano zirconium dioxide to produce a novel heterogeneous reusable solid acid nanocatalyst. This new nanocatalyst is characterized by FT-IR spectroscopy, thermogravimetric analysis (TGA), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), the Hammett acidity function and pH analysis. The introduced nano-zirconia-supported sulfonic acid is used as an efficient and recyclable catalyst for different heterocyclic multicomponent reactions such as the synthesis of hexahydroquinoline, 1,8-dioxo-decahydroacridine, polyhydroquinoline and 1,8-dioxo-octahydroxanthene derivatives. Optimization of the reaction conditions was studied using a central composite design (CCD) which is one of the most widely used response surface methodologies. The newly prepared heterogeneous solid acid nanocatalyst is easily separated and reusable for five cycles without any apparent loss of its catalytic activity, which confirmed the stability of the covalent bonding of the sulfonic acid groups. n-ZrSA has advantages such as its low cost, low toxicity, ease of preparation, good stability, high reusability and operational simplicity.

A new type of SO3H-functionalized magnetic-titania as a robust magnetically-recoverable solid acid nanocatalyst for multi-component reactions

SO3H-functionalized magnetic-titania nanoparticles (Fe3O4@TDI@TiO2-SO3H) have been synthesized by a two-step procedure, involving the covalent grafting of n-TiO2 to n-Fe3O4via 2,4-toluene diisocyanate as a regioselective linker (n-Fe3O4@TDI@TiO2) and subsequent sulfonation using chlorosulfonic acid. The as-prepared nanocatalyst was characterized by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and vibrating sample magnetometry (VSM). The catalytic activity of the nanocatalyst was assessed for the synthesis of benzimidazoquinazolinones and polyhydroquinolines, in which the reaction conditions were optimized by applying central composite design (CCD) through response surface methodology. The nanocatalyst could be separated from the reaction mixture easily by magnetic decantation and reused at least six times without a noticeable degradation in catalytic activity. To the best of our knowledge, there are no literature reports on applying experimental design to optimize the reaction conditions for benzimidazoquinazolinones synthesis.

MoO2Cl2 catalyzed efficient synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones and polyhydroquinolines: recyclability, fluorescence and biological studies

A simple, facile and efficient synthesis of functionalized dihydropyrimidinones and polyhydroquinolines using molybdenum(vi) dichloride dioxide (MoO2Cl2) has been developed. The present protocol demonstrates the exceptional tolerance