33358-30-4

Upstream product

• 162010-78-8 4-chlorosulfonyl-3-nitrobenzoic acid methyl ester 
• 930-69-8 sodium thiophenolate 
• 89976-27-2 methyl ester of 4-iodo-3-nitrobenzoic acid 
• 2363-16-8 methyl 4-bromo-3-nitrobenzoate 
• 14719-83-6 methyl 3-nitro-4-chlorobenzoate 

Downstream Products

• 874524-03-5 3-[N'-(3-[1,3]dioxolan-2-yl-phenyl)-ureido]-4-phenylsulfanyl-benzoic acid methyl ester 
• 874523-90-7 3-amino-4-phenylsulfanyl-benzoic acid methyl ester 

Relevant academic research and scientific papers

Benzenesulfonamide compounds

The present invention provides a benzenesulfonamide compound represented by chemical formula 1 or a biotinylated compound thereof. The compounds of the present invention selectively react with a sulfhydryl group (-SH) having unoxidized cysteine, and do no

Nucleophilic Substitution Reactions of 1-Halogeno-4-COR-2-nitrobenzenes and 1-Halogeno-6-COR-2-nitrobenzenes with Sodium Benzenethiolate and Piperidine. Can an "Inverted Built-in Solvation" Be Responsible for the Peculiar Activation by an o-Carboxamido Group in SNAr Reactions with an Anionic Nucleophile?

A kinetic study of the title reactions has allowed an interpretation of the higher efficiency of an o-carboxamido group with respect to an o-carbomethoxy group in activating the benzenethiolate-dehalogenation reactions in methanol (kCONH2/kCO2Me 2.2-3.0) as due to an interaction between the anionic nucleophile and the hydrogen atoms of the carboxamido group. An inversion of the activating power of the two groups (kCONH2/kCO2Me 0.14) in the reactions with the same nucleophile has been observed when they are in a para-position. Moreover, for piperidino-dehalogenation reactions in methanol kCONH2/kCO2Me ratios less than unity (0.2-0.6) have been observed independently of the position (ortho or para) of the carboxamido and carbomethoxy groups with respect to the reaction center.