3337-87-9Relevant academic research and scientific papers
Synthesis of new quinazoline derivatives
Baitiche, Milad,Mahamoud, Abdallah,Benachour, Djaffar,Merbah, Meriem,Barbe, Jacques
, p. 269 - 272 (2004)
New quinazoline derivatives were prepared by the reaction of 4-hydroxy-quinazoline with alkyl halides under phase transfer-catalysis conditions. The hydroxy group was readily converted into a thiol function by treating with phosphorus pentasulfide in pyridine and the subsequent alkylation of the thiol group was carried out under PTC conditions. Chlorination of 4-hydroxyquinazoline was carried out with phosphorus oxychloride. Branching of alkylamino side chains to the 4-OH, 4-S, and 4-Cl quinazolines has resulted in the synthesis of several compounds identified by 1H NMR.
