Heterocyclic Communications p. 269 - 272 (2004)
Update date:2022-08-11
Topics:
Baitiche, Milad
Mahamoud, Abdallah
Benachour, Djaffar
Merbah, Meriem
Barbe, Jacques
New quinazoline derivatives were prepared by the reaction of 4-hydroxy-quinazoline with alkyl halides under phase transfer-catalysis conditions. The hydroxy group was readily converted into a thiol function by treating with phosphorus pentasulfide in pyridine and the subsequent alkylation of the thiol group was carried out under PTC conditions. Chlorination of 4-hydroxyquinazoline was carried out with phosphorus oxychloride. Branching of alkylamino side chains to the 4-OH, 4-S, and 4-Cl quinazolines has resulted in the synthesis of several compounds identified by 1H NMR.
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