333999-58-9

Basic information

• Product Name: (1S,3S,6S,7S,8R)-7-acetoxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-5-azatricyclo[6.3.1.0^1,5]dodecan-4,9-dione
• Synonyms: (1S,3S,6S,7S,8R)-7-acetoxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-5-azatricyclo[6.3.1.0^1,5]dodecan-4,9-dione
• CAS NO: 333999-58-9
• Molecular Weight: 554.664
• Mol File: 333999-58-9.mol

Chemical Properties

• CAS DataBase Reference: (1S,3S,6S,7S,8R)-7-acetoxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-5-azatricyclo[6.3.1.0^1,5]dodecan-4,9-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,3S,6S,7S,8R)-7-acetoxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-5-azatricyclo[6.3.1.0^1,5]dodecan-4,9-dione(333999-58-9)
• EPA Substance Registry System: (1S,3S,6S,7S,8R)-7-acetoxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-5-azatricyclo[6.3.1.0^1,5]dodecan-4,9-dione(333999-58-9)

Safety Data

• Hazardous Substances Data: 333999-58-9(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 4089-07-0 L-tyrosine ethyl ester monohydrochloride 
• 60-18-4 L-tyrosine 
• 58559-09-4 Ethyl N-(p-tosyl)tyrosinate 
• 333999-53-4 (3S,1S')-1-[2'-acetoxy-1'-(4-methoxybenzyl)-ethyl]-3-[N-acetyl-N-(4-methylphenyl)sulfonylamino]-1-azaspiro[4.5]decan-2,8-dione 
• 333999-52-3 (3S,1S')-1-[2'-acetoxy-1'-(4-methoxybenzyl)-ethyl]-3-[N-acetyl-N-(4-methylphenyl)sulfonylamino]-1-azaspiro[4.5]deca-6,9-dien-2,8-dione 
• 333999-55-6 (3S,1S')-1-[2'-hydroxy-1'-(4-methoxybenzyl)-ethyl]-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-1-azaspiro[4.5]decan-2,8-dione 
• 333999-54-5 (3S,1S')-1-[2'-hydroxy-1'-(4-methoxybenzyl)-ethyl]-3-[N-(4-methylphenyl)sulfonylamino]-1-azaspiro[4.5]decan-2,8-dione 
• 333999-56-7 (3S,1S')-1-[1'-formyl-2'-(4-methoxyphenyl)-ethyl]-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-1-azaspiro[4.5]decan-2,8-dione 
• 333999-50-1 (S)-2-{(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl}-4-(4-methoxybenzyl)-2-oxazoline 
• 333999-51-2 N-{(S)-1-[(S)-1-Hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-2,8-dioxo-1-aza-spiro[4.5]deca-6,9-dien-3-yl}-4-methyl-benzenesulfonamide 
• 4703-32-6 (S)-2-[N-(4-methylphenyl)sulfonylamino]-3-(4-hydroxyphenyl) propionic acid 
• 108-24-7 acetic anhydride 
• 333999-57-8 (1S,3S,6S,7S,8R)-7-hydroxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-5-azatricyclo[6.3.1.0^1,5]dodecan-4,9-dione 

Downstream Products

• 333999-59-0 (1S,3S,6S,7S,8R,9R)-7-acetoxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-9-[(4-nitrophenyl)sulfonyloxy]-5-azatricyclo[6.3.1.0^1,5]dodecan-4-one 
• 333999-60-3 (1S,3S,6S,7S,8S,9S)-7,9-diacetoxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-5-azatricyclo[6.3.1.0^1,5]dodecan-4-one 
• 333999-62-5 (1S,3S,6S,7S,8S,9S)-3-(N-benzyloxycarbonyl-N-methylamino)-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1,5]dodecane-7,9-diol 
• 333999-61-4 (1S,3S,6S,7S,8S,9S)-6-(4-methoxybenzyl)-3-(N-methylamino)-5-azatricyclo[6.3.1.0^1,5]dodecane-7,9-diol 
• 248948-75-6 (2S,5S,6S,7R,8S,10aS)-2-[[(benzyloxy)carbonyl]methylamino]octahydro-6-hydroxy-5-[(4-methoxyphenyl)methyl]-1H-7,10a-methanopyrrolo[1,2-a]azocin-8-yl dibenzyl phosphate 
• 331665-37-3 (1S,3S,6S,7S,8S,9R)-7-acetoxy-9-hydroxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-5-azatricyclo[6.3.1.0^1,5]dodecan-4-one 

Relevant articles and documents

Synthetic ventures inspired by biosynthetic hypotheses: the evolution of a method for the oxidative amidation of phenols

We describe the development of a technique for the oxidative conversion of 4-alkyl phenols to derivatives of the corresponding 4-alkyl-4-amino-2,5-cyclohexanediones. This transformation, which was inspired by biogenetic considerations, constitutes a key s

Total synthesis of tricyclic azaspirane derivatives of tyrosine: FR901483 and TAN1251C

A solution to the long-standing problem presented by the oxidative cyclization of a phenolic 3-arylpropionamide to a spirolactam has been developed in this laboratory via oxazoline chemistry. This research was motivated by our interest in some novel tricyclic azaspirane natural products formally derived from tyrosine, such as FR901483 and TAN1251C. In this paper, we disclose full details of the total synthesis of these substances.