58559-09-4Relevant academic research and scientific papers
Total synthesis of FR901483
Ousmer, Malika,Braun, Norbert A.,Ciufolini, Marco A.
, p. 765 - 767 (2007/10/03)
The total synthesis of FR901483, a structurally novel immunosuppressant, has been accomplished by the use of technology recently developed in this laboratory for the oxidative cyclization of phenolic oxazolines to spirolactams. Our approach may reflect th
Total synthesis of tricyclic azaspirane derivatives of tyrosine: FR901483 and TAN1251C
Ousmer,Braun,Bavoux,Perrin,Ciufolini
, p. 7534 - 7538 (2007/10/03)
A solution to the long-standing problem presented by the oxidative cyclization of a phenolic 3-arylpropionamide to a spirolactam has been developed in this laboratory via oxazoline chemistry. This research was motivated by our interest in some novel tricyclic azaspirane natural products formally derived from tyrosine, such as FR901483 and TAN1251C. In this paper, we disclose full details of the total synthesis of these substances.
Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1
Dhanak, Dashyant,Christmann, Lisa T.,Darcy, Michael G.,Jurewicz, Anthony J.,Keenan, Richard M.,Lee, Judithann,Sarau, Henry M.,Widdowson, Katherine L.,White, John R.
, p. 1441 - 1444 (2007/10/03)
The discovery of a series of phenylalanine derived CCR3 antagonists is reported. Parallel, solution-phase library synthesis has been utilized to delineate the structure-activity relationship leading to the synthesis of highly potent, CCR3-selective antagonists.
