33407-02-2Relevant articles and documents
Alkylation of dichlorobenzene isomers by olefins on zeolites Y and pentasil
Lishchiner, I. I.,Plakhotnik, V. A.,Kuz'micheva, A. N.,Mortikov, E. S.,Borisov, Yu. A.
, p. 1428 - 1429 (1995)
Catalytic alkylation of dichlorobenzene isomers by ethylene and propylene on zeolite catalysts has been studied.It has been determined that using catalysts based on zeolite Y makes it possible to change the ratio of 1-alkyldichlorobenzenes formed within a wide range by varying the acidic properties of the catalysts. - Keywords: alkylation, dichlorobenzenes, olefins, zeolites
Proton mobility in 2-substituted 1,3-dichlorobenzenes: "ortho" or "meta" metalation?
Schlosser, Manfred,Heiss, Christophe,Marzi, Elena,Scopelliti, Rosario
, p. 4398 - 4404 (2007/10/03)
Nine 1,3-dichlorobenzene congeners were selected as model compounds to assess the relative rates of proton abstraction from 4- and 5-positions ("ortho" vs. "meta" metalation). Using lithium 2,2,6,6-tetramethylpiperidide as the basic reagent, the chlorine-adjacent 4-position underwent metalation exclusively. In contrast, attack at the chlorine-remote 5-posi" tion became significant even in the case of moderately sized 2-substituents (such as dimethylamino or ethyl) when secbutyllithium was employed. The "ortho/para" (4-/5-) ratios ranged from 80:20 to 65:35. The more pronounced "meta-orienting" effect of silicon as opposed to carbon substituents can be attributed to dissimilarities in the n polarization of the aromatic ring. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
Studies on 6-aminoquinolones: Synthesis and antibacterial evaluation of 6-amino-8-ethyl- and 6-amino-8-methoxyquinolones
Cecchetti, Violetta,Tabarrini, Oriana,Sabatini, Stefano,Miao, Hua,Filipponi, Enrica,Fravolini, Arnaldo
, p. 2465 - 2471 (2007/10/03)
From our quantitative structure-activity relationship (QSAR) study on a large set of 6-aminoquinolones, which indicated that a group larger than methyl could be allocated at C-8 position, we have synthesized two new series of 6-aminoquinolones characteriz