33421-59-9

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 520-45-6 Dehydracetic acid 
• 100-63-0 phenylhydrazine 
• 771-03-9 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one 
• 294874-70-7 5-acetonyl-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 75-36-5 acetyl chloride 
• 54107-17-4 3-(2-phenylhydrazonoethyl)-4-hydroxy-6-methylpyrone-2-one 

Downstream Products

• 143035-39-6 3,6-Dimethyl-1-phenyl-1,5-dihydro-pyrazolo[4,3-c]pyridine-4-thione 
• 13945-10-3 3,6-dimethyl-1-phenyl-1,5-dihydro-pyrazolo[4,3-c]pyridin-4-one 
• 143035-37-4 3,6-dimethyl-1-phenyl-1H-pyrazolo<4,3-c>pyrane-4-thione 
• 294874-70-7 5-acetonyl-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and inotropic activity of pyrazolo[4,3-c]pyridine-4-ones and related compounds

Two series of 3,6-dimethyl-1-phenyl-1H-pyrazolo[4,3-c]pyridine-4-ones (5- 9) and 3,6-dimethyl-1-phenyl-1H-pyrazolo[4,3-c]pyridine-4-thiones (11-13) were prepared from dehydroacetic acid as starting material and evaluated for positive inotropic activity in

Synthesis of Pyranopyrazol-4(1H)-ones and -4(2H)-ones from Dehydroacetic Acid. Homo- and Heteronuclear Selective NOE Measurements for Unambiguous Structure Assignment

Cyclization of dehydroacetic acid N-substituted hydrazones furnished 1-substituted 3,6-dimethylpyranopyrazol-4(1H)-ones, together with varying amounts of N,N'-disubstituted 5-hydroxy-3-methyl-4-(3-methyl-1H-pyrazol-5-yl)-1H-pyrazoles.The same pyranopyrazolones were obtained regioselectively without side reactions from N-alkylhydrazines and 4-chloro-3-(1-chlorovinyl)-6-methyl-2H-pyran-2-one, ("Dehydroacetchlorid"), while N-arylhydrazines gave the 2-aryl-3,6-dimethylpyranopyrazol-4(2H)-ones.NMR NOE methods, including long-range selective heteronuclear 13C NOE enhancement measurements, allowed unambiguous between -4(1H)-ones and -4(2H)-ones.