33422-33-2Relevant academic research and scientific papers
Synthesis and biological activity of anthelmintic thiadiazoles using an AF-2 receptor binding assay
Lee, Byung H.,Dutton, Fred E.,Clothier, Michael F.,Bowman, Jerry W.,Davis, John P.,Johnson, Sandra S.,Thomas, Eileen M.,Zantello, Marjorie R.,Zinser, Erich W.,McGuire, James C.,Thompson, David P.,Geary, Timothy G.
, p. 1727 - 1732 (2007/10/03)
Following our discovery of the strong binding of thiadiazole 1 to the AF-2 neuropeptide receptor of gastrointestinal nematodes (e.g., Ascaris suum), we prepared two series of analogs. Only the series containing the thiadiazole ring had potencies comparable to that of compound 1. Analog 50 exhibited an apparent potency in the AF-2 binding assay 300 times that of compound 1.
New Azoolefines and their Acidic Cleavage to Aryldiimines
Kirschke, Klaus,Moeller, Angela,Schmitz, Ernst
, p. 893 - 898 (2007/10/02)
3-Amino-1-aryl-3',3'-dimethyl-pyrazolin-4-spiro-2'-oxiran-5-ones (3a-c) undergo ring opening with methoxide forming methyl 3-amino-3-arylazo-propenoates (5a-c). 5a-c are cleaved under acidic conditions.The main products of the cleavage of 5c with methanolic hydrochloric acid are nitrogen, 2,4,6-trichloro-benzene (6), 2,4,6-trichloro-aniline (9) and 2,4,6-trichloro-phenylhydrazine (10).Intermediates of the cleavage of 5 are aryldiimines trapped with benzaldehyde as the corresponding benzhydrazides (12a,b).
