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Usage

Uses

Used in Pharmaceutical Industry:
Ketotifen is used as an antihistamine and mast cell stabilizer for the treatment of allergic conditions such as allergic rhinitis and asthma. Its non-competitive H1-antihistamine action helps reduce the release of histamine and other inflammatory mediators, while its anti-inflammatory and bronchodilator properties contribute to symptom management.
Used in Allergy Treatment:
Ketotifen is employed as a therapeutic agent for the management of allergic symptoms, including those associated with allergic rhinitis and asthma. Its dual action as a non-competitive H1-antihistamine and mast cell stabilizer makes it effective in controlling inflammation and preventing the release of histamine, thereby alleviating allergic reactions.
Used in Various Formulations:
Ketotifen is available in different forms, such as tablets, eye drops, and oral syrup, catering to the diverse needs of patients with allergic conditions. This versatility allows for targeted treatment and ease of administration, enhancing patient compliance and treatment outcomes.

Upstream product

• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 100-52-7 benzaldehyde 
• 613-90-1 benzoyl cyanide 
• 1074-12-0 phenylglyoxal hydrate 
• 121-69-7 N,N-dimethyl-aniline 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 6317-85-7 4-(dimethylamino)benzoin 

Downstream Products

• 6317-85-7 4-(dimethylamino)benzoin 
• 99052-55-8 4--2,2-dimethyl-5-phenyl-3-imidazolin 
• 79213-82-4 5--2,2-dimethyl-4-phenyl-Δ³-1,3-oxazolin 
• 85004-28-0 (Z)-1-(4-Dimethylamino-phenyl)-2-phenyl-ethene-1,2-dithiol 
• 22711-20-2 1-(4-dimethylaminophenyl)-2-phenyl-1,2-ethanedione 
• 7532-77-6 2,5-Bis-3,6-diphenylpyrazin 
• 6266-95-1 1-phenyl-2-<4-(N,N-dimethylamino)phenyl>ethanone 
• 619-84-1 p-N,N-dimethylaminobenzoic acid 
• 65-85-0 benzoic acid 
• 74266-39-0 2,2-bis-(4-dimethylamino-phenyl)-1-phenyl-ethanone 

Relevant academic research and scientific papers

Reaction of Arylglyoxals with Electron-Rich Benzenes and π-Excessive Heterocycles. Facile Synthesis of Heteroaryl α-Acyloins

The reaction of arylglyoxals and their hydrates with electron-rich benzenes and π-excessive heterocycles, if conducted in the absence of catalysts, affords α-benzoins.

Reductive Coupling of Benzoyl Cyanide and Carbonyl Compounds by Aqueous Ti(III) Ions. A New Convenient and Selective Access to the Less Stable Mixed Benzoins

The reactive species formed by the Ti(III) ion reduction of benzoyl cyanide (1) adds to the C-atom of carbonyl compounds 2 under simple experimental conditions.The intermediate 1,2-diols 3 are smoothly converted, without isolation, into the less thermodynamically stable mixed benzoins 4, which are not accessible by the classical benzoin condensation.The possible mechanisms involved in the reaction are discussed.

66. Synthese und Reaktionen des 5--2,2-dimethyl-4-phenyl-3-oxazolins

Synthesis and Reactions of 5--2,2-dimethyl-4-phenyl-3-oxazoline.The title compound 8 has been synthesized in a one-pot reaction of 4'-(dimethylamino)benzoin (4) with 2-propanone and NH3.The preparation of the intermediate 4 from 3 is the first example of an acid-catalyzed transformation of the stable benzoin 3 into the corresponding less stable benzoin 4.Structures and yields of various by-products occuring under different reaction conditions during the synthesis of 8 from 4 are given.The O-atom of the 3-oxazoline ring in 8 could be replaced by S from P2S5 yielding the 3-thiazoline 14.Separation of the enantiomers of the racemate 8 could only be performed by transforming them into the trimethylanilinium salts 8b and 8c of (-)- and (+)-10-camphorsulfonic acid, respectively.Solid NaOAc in boiling toluene caused the precipitation of the 10-camphorsulfonic acids from the quaternary ammonium salts as sodium salts and the removing of the third methyl group from the quaternary ammonium salts as AcOMe to give the enantiomers (-)-(5S)-8 and (+)-(5R)-8.Their absolute configurations are deduced from an X-ray analysis of 8b.

SOLVENT EFFECTS ON THE ELECTRONIC STRUCTURE OF BIS(4-DIMETHYLAMINODITHIOBENZYL) NICKEL II(4-DMAB)> FROM UV-VIS AND EPR SPECTRA

The UV-VIS and EPR spectra of solutions of NiII(4-DMAB) in 10 solvents with donor number (DN) from 0.1 to 38.8 have been recorded.The changes in the spectra are explained in terms of a change in symmetry of the NiII(4-DMAB) complex on increase in donor number of the solvent.The symmetry change is from square planar to rhombic bipyramidal with corresponding change in electronic configuration of the nickel ion from d2z2 to d1z2, d1x2-y2.Light was observed to accelerate this structural change.