334708-46-2

Upstream product

• 67-56-1 methanol 
• 334708-41-7 [2R,3S,1'S,2'S]-(+)-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-N,2-dimethyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)propanamide 
• 130632-09-6 (E)-1-(3,4-dimethoxyphenyl)-N-(4-methoxyphenyl)methanimine 

Relevant academic research and scientific papers

(+)-(S,S)-pseudoephedrine as a chiral auxiliary in asymmetric Mannich reactions: Scope and limitations

The Mannich reaction of variously substituted (+)-(S,S)-pseudoephedrine amides with either enolizable and nonenolizable imines smoothly afforded a series of β-substituted α-alkyl-β-amino amides with full stereochemical control. These Mannich adducts have

Asymmetric synthesis of beta-substituted alpha-methyl-beta-amino esters by Mannich reaction of (S,S)-(+)-pseudoephedrine acetamide derived enolate with imines.

[reaction: see text]. The reaction of an (S,S)-(+)-pseudoephedrine acetamide based enolate with several imines afforded smoothly and with full stereochemical control a series of beta-substituted alpha-methyl-beta-aminoamides that upon hydrolysis/esterific