33471-66-8

Basic information

• Product Name: 1-Benzyl-4,5-diphenyl-1H-1,2,3-triazole
• Synonyms: 1-Benzyl-4,5-diphenyl-1H-1,2,3-triazole;4,5-Diphenyl-1-benzyl-1H-1,2,3-triazole
• CAS NO: 33471-66-8
• Molecular Formula: C₂₁H₁₇N₃
• Molecular Weight: 0
• Mol File: 33471-66-8.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 492.7°C at 760 mmHg
• Flash Point: 251.8°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 7.5E-10mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 1-Benzyl-4,5-diphenyl-1H-1,2,3-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-4,5-diphenyl-1H-1,2,3-triazole(33471-66-8)
• EPA Substance Registry System: 1-Benzyl-4,5-diphenyl-1H-1,2,3-triazole(33471-66-8)

Safety Data

• Hazardous Substances Data: 33471-66-8(Hazardous Substances Data)

Usage

Chemical class

Triazole compounds

Heterocyclic structure

Contains a five-membered ring of two carbon atoms and three nitrogen atoms

Aromatic properties

Due to the presence of benzyl and phenyl groups attached to the triazole ring

Potential applications

Medicinal chemistry, pharmaceuticals, and agrochemicals

Biological activities

Antimicrobial and antitumor effects

Research focus

Drug discovery and development

Additional uses

Ligand in transition metal catalysis and building block in the synthesis of complex organic compounds

InChI:InChI=1/C21H17N3/c1-4-10-17(11-5-1)16-24-21(19-14-8-3-9-15-19)20(22-23-24)18-12-6-2-7-13-18/h1-15H,16H2

Upstream product

• 501-65-5 diphenyl acetylene 
• 622-79-7 benzyl azide 
• 106-95-6 allyl bromide 
• 536-74-3 phenylacetylene 
• 98-80-6 phenylboronic acid 
• 142108-79-0 2-(4-methoxyphenyl)-4,5-diphenyl-2H-1,2,3-triazole 
• 100-39-0 benzyl bromide 
• 120106-62-9 4,5-diphenyl-2H-1,2,3-triazole 
• 451-40-1 phenyl benzyl ketone 
• 952-06-7 deoxybenzoin oxime 
• 16483-98-0 2,3-diphenyl-2H-azirine 
• 637-44-5 phenylpropyolic acid 
• 13146-23-1 copper(I) phenylacetylenide 
• 1228000-48-3 1-benzyl-5-chloro-4-phenyl-1H-[1,2,3]triazole 

Relevant articles and documents

Insight into the Mechanism of the CuAAC Reaction by Capturing the Crucial Au4Cu4-π-Alkyne Intermediate

The classic Fokin mechanism of the CuAAC reaction of terminal alkynes using a variety of Cu(I) catalysts is well-known to include alkyne deprotonation involving a bimetallic σ,π-alkynyl intermediate. In this study, we have designed a CNT-supported atomica

General Synthesis of Tri-Carbo-Substituted N2-Aryl-1,2,3-triazoles via Cu-Catalyzed Annulation of Azirines with Aryldiazonium Salts

The general synthesis of fully substituted N2-aryl-1,2,3-triazoles is hitherto challenging compared with that of the N1-aryl counterparts. Herein, we describe a Cu-catalyzed annulation reaction of azirines and aryldiazonium salts. This regiospecific metho

An enolate-mediated regioselective synthesis of 1,2,3-triazoles via azide-aldehydes or ketones [3+2]-cycloaddition reactions in aqueous phase

A synthetic route for the direct conversion of arylazides into the corresponding trizoles via phase transfer catalyst-assisted [3+2] cycloaddition reaction under basic conditions in aqueous medium is reported. This synthetic methodology, which offers high