334792-90-4

Basic information

• Product Name: methyl 3-(4-azidopiperidin-1-yl)-5-(trifluoromethyl)benzoate
• Synonyms: methyl 3-(4-azidopiperidin-1-yl)-5-(trifluoromethyl)benzoate
• CAS NO: 334792-90-4
• Molecular Weight: 328.294
• Mol File: 334792-90-4.mol

Chemical Properties

• CAS DataBase Reference: methyl 3-(4-azidopiperidin-1-yl)-5-(trifluoromethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(4-azidopiperidin-1-yl)-5-(trifluoromethyl)benzoate(334792-90-4)
• EPA Substance Registry System: methyl 3-(4-azidopiperidin-1-yl)-5-(trifluoromethyl)benzoate(334792-90-4)

Safety Data

• Hazardous Substances Data: 334792-90-4(Hazardous Substances Data)

Upstream product

• 22235-25-2 3-amino-5-trifluoromethylbenzoic acid methyl ester 
• 22227-63-0 methyl 3-nitro-5-(trifluoromethyl)-benzoate 
• 328-80-3 3-nitro-5-trifluoromethyl-benzoic acid 
• 334792-88-0 methyl 3-(4-hydroxypiperidin-1-yl)-5-(trifluoromethyl)benzoate 
• 334792-87-9 Methyl 3-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)benzoate 
• 334792-89-1 methyl 3-{4-(methanesulfonyloxy)-piperidin-1-yl}-5-(trifluoromethyl)benzoate 

Downstream Products

• 334792-94-8 tert-butyl (2S)-benzenesulfonylamino-3-[3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoylamino]propionate 
• 334792-95-9 (2S)-benzenesulfonylamino-3-[3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoylamino]propionic acid 
• 334792-93-7 3-(4-(pyrimidin-2-ylamino)piperidin-1-yl)-5-(trifluoromethyl)benzoic acid 
• 334792-92-6 methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate 
• 334792-91-5 methyl 3-(4-aminopiperidin-1-yl)-5-(trifluoromethyl)benzoate 

Relevant articles and documents

Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part IV: Preliminary control of αvβ3 selectivity by meta-oriented substitution

To establish the in vivo efficacy of αvβ3/αIIbβ3 dual antagonists possessing a tricyclic pharmacophore, a corresponding αvβ3-selective antagonist was required as a control. We initially too

m-SUBSTITUTED BENZOIC ACID DERIVATIVES EXHIBITING INTEGRIN ALPHA-V BETA-3 ANTAGONISM

An object of the present invention is to provide m-substituted benzoic acid derivatives having integrin αvβ3 antagonistic activity. The derivatives according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof, which are useful for the treatment or prevention of cardiovascular diseases, angiogenesis-related diseases, cerebrovascular diseases, cancers and metastasis thereof, immunological diseases, osteopathy and other diseases: wherein A represents an optionally substituted heterocyclic group containing two nitrogen atoms, a bicylic group or the like; D represents a bond, >NR4, >CR5R6, O, S, or -NR4-CR5R6-; X represents CH or N; R7 and R8 represent hydroxyl, alkyl or the like; Q represents >C=O or the like; R9 represents hydrogen, alkyl or the like; J represents a bond or alkylene; R10 represents optionally substituted hydroxyl, amino or the like; R11 represents hydrogen, alkyl or the like; m is 0 to 5; n is 0 to 4; and p and q are each 0 to 3.