334793-69-0

Upstream product

• 131446-96-3 (S)-2-(benzyloxy)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzenesulfonate 
• 333788-77-5 (2R,3R)-2-Benzyloxy-3-(1-methoxy-1-methyl-ethoxy)-succinic acid diethyl ester 
• 333788-78-6 (2S,3S)-2-Benzyloxy-3-(1-methoxy-1-methyl-ethoxy)-butane-1,4-diol 
• 119770-87-5 (2R,3R)-diethyl 2-(benzyloxy)-3-hydroxysuccinate 
• 84379-53-3 2-O-benzyl-3,4-O-isopropylidene-L-threitol 

Downstream Products

• 333788-83-3 Methanesulfonic acid (Z)-(1R,6R,7S)-7-benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-1-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-ethyl]-non-3-enyl ester 
• 333788-71-9 (2R,3R,8R,9S)-9-Benzyloxy-2,8-bis-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-undec-5-yn-3-ol 
• 333788-82-2 (Z)-(2R,3R,8R,9S)-9-Benzyloxy-2,8-bis-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-undec-5-en-3-ol 
• 333788-87-7 Acetic acid (Z)-(S)-1-[(2R,7R)-7-((S)-1-benzyloxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-5-(tetrahydro-pyran-2-yloxy)-pent-3-enyl ester 
• 333788-73-1 (S)-1-[(2R,7R)-7-((S)-1-Benzyloxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-5-(tetrahydro-pyran-2-yloxy)-pent-3-yn-1-ol 
• 333788-86-6 (Z)-(S)-1-[(2R,7R)-7-((S)-1-Benzyloxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-5-(tetrahydro-pyran-2-yloxy)-pent-3-en-1-ol 
• 333788-84-4 Methanesulfonic acid (R)-1-[(2R,7R)-7-((S)-1-benzyloxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-2-(4-methoxy-benzyloxy)-ethyl ester 
• 333788-68-4 (Z)-(3S,4R)-3-Benzyloxy-8-[(2S,3R)-3-(4-methoxy-benzyloxymethyl)-oxiranyl]-oct-6-en-4-ol 
• 333788-67-3 (R)-1-[(2R,7R)-7-((S)-1-Benzyloxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-2-(4-methoxy-benzyloxy)-ethanol 
• 333788-74-2 Acetic acid (Z)-(S)-1-[(2R,7R)-7-((S)-1-benzyloxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-5-hydroxy-pent-3-enyl ester 
• 333788-75-3 (Z)-(S)-1-[(2R,7R)-7-((S)-1-Benzyloxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-hex-3-en-5-yn-1-ol 
• 333788-72-0 Methanesulfonic acid (R)-1-[(2R,7R)-7-((S)-1-benzyloxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-2-hydroxy-ethyl ester 
• 333788-76-4 (2R,7R)-2-((S)-1-Benzyloxy-propyl)-7-((Z)-(R)-1-chloro-hex-3-en-5-ynyl)-2,3,6,7-tetrahydro-oxepine 
• 333788-80-0 Methanesulfonic acid (1S,2S)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-butyl ester 

Relevant academic research and scientific papers

The first total synthesis of (+)-rogioloxepane A

The first total synthesis of (+)-rogioloxepane A is described. The α,ω-trans-disubstituted oxepene skeleton was stereoselectively constructed via cyclization of the hydroxy epoxide promoted by the (Bu3Sn)2O/Zn(OTf)2 system. The proposed configurations of 6R and 13R were confirmed through this synthetic study.